Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?

Table 1 Demographic features and laboratory values of the patients and controls

	Acute pancreatitis (n = 117)	Control group (n = 34)	P value
Age (yr)	46.98 ± 14.42	50.53 ± 12.18	0.1171
Gender (M/F)	72 (61.5%)/45 (38.5%)	19 (55.9%)/15 (44.1%)	0.5572
MPV (fL)	8.72 ± 2.37	10.98 ± 1.40	0.00061
WBC (× 109/L)	13.28 ± 3.84	5.99 ± 1.64	0.0001
Platelet (× 109/L)	180.00 ± 65.04	203.56 ± 52.73	0.0601
AT-III (%)	90.93 ± 19.00	101.44 ± 10.36	0.0001
APTT (S)	37.96 ± 14.12	36.79 ± 4.14	0.6351
PT (S)	12.85 ± 1.14	12.63 ± 0.62	0.1441
FIB (g/L)	3.68 ± 1.45	2.91 ± 0.51	0.0001
D-D (μg/mL)	1.16 ± 1.14	0.27 ± 0.16	0.0001
Hb (g/L)	143.69 ± 26.04	147.53 ± 14.76	0.4211
Hct (%)	42.91 ± 6.46	44.75 ± 4.51	0.1281

¹t-test;

²χ² test. MPV: Mean platelet volume; WBC: White blood cells; AT-III: Antithrombin III; APTT: Activated partial prothrombin time; PT: Prothrombin time; FIB: Fibrinogen; D-D: D-dimers; Hb: Hemoglobin; Hct: Hematocrit.

Table 2 Mean platelet volume levels in acute pancreatitis patients (on days 1, 2, 3 and 7 after admission) and controls

AP Patients				Controls	F value	P value
MPV1a (fL)	MPV2ac (fL)	MPV3ac (fL)	MPV7c (fL)
8.72 ± 2.37	9.67 ± 2.37	9.77 ± 1.84	10.44 ± 1.66	10.98 ± 1.40	13.92	0.000

^aP < 0.05 vs control group;

^cP < 0.05 vs mean platelet volume (MPV) on day 1 after admission. AP: Acute pancreatitis.

Table 3 Mean platelet volume, white blood cells, lactate dehydrogenase and C-reactive protein on days 1, 2, 3 and 7 after admission between mild and severe acute pancreatitis according to the Modified Glasgow Prognostic Score

	Mild pancreatitis (n = 78)	Severe pancreatitis (n = 39)	t	P value
MPV1 (fL)	8.85 ± 2.32	8.47 ± 2.49	0.802	0.424
MPV2 (fL)	9.66 ± 2.32	9.67 ± 2.49	-0.024	0.981
MPV3 (fL)	9.68 ± 1.84	9.96 ± 1.84	-0.791	0.430
MPV7 (fL)	10.40 ± 1.59	10.52 ± 1.80	-0.357	0.721
WBC1 (× 109/L)	12.26 ± 3.62	15.33 ± 3.47	-4.387	0.000
WBC2 (× 109/L)	10.52 ± 3.63	13.26 ± 4.78	-3.456	0.001
WBC3 (× 109/L)	8.51 ± 0.19	10.69 ± 3.56	-3.356	0.001
WBC7 (× 109/L)	6.82 ± 2.26	9.53 ± 3.80	-4.831	0.001
LDH1 (U/L)	230.70 ± 79.79	280.15 ± 102.28	-2.870	0.005
LDH2 (U/L)	187.49 ± 51.72	258.95 ± 103.09	-4.080	0.000
LDH3 (U/L)	181.17 ± 44.77	242.05 ± 84.61	-4.209	0.000
LDH7 (U/L)	180.29 ± 46.22	227.25 ± 58.69	-4.366	0.000
CRP1 (mg/L)	42.53 ± 71.33	66.85 ± 96.00	-1.398	0.167
CRP2 (mg/L)	76.83 ± 69.50	129.77 ± 111.28	-2.718	0.009
CRP3 (mg/L)	68.62 ± 61.01	154.05 ± 114.50	-4.361	0.000
CRP7 (mg/L)	23.12 ± 31.93	66.49 ± 57.40	-4.391	0.000

MPV: Mean platelet volume; WBC: White blood cells; LDH: Lactate dehydrogenase; CRP: C-reactive protein.

Table 4 Overall accuracy of mean platelet volume and other inflammation makers in predicting severe acute pancreatitis on days 1, 2 and 3 after admission according to the Modified Glasgow Prognostic Score

	Cut-off value	AUC	Sensitivity	Specificity	PPV	NPV	Overall accuracy (%)
MPV1 (fL)	7.45	0.540	73.1	38.5	41.67	70.37	61.54
WBC1 (× 109/L)	15.20	0.737	59.0	82.1	62.16	80.00	74.36
LDH1 (U/L)	192.45	0.669	92.3	42.3	44.44	91.67	58.97
WBC2 (× 109/L)	11.47	0.675	64.1	65.4	48.08	78.46	64.96
LDH2 (U/L)	189.60	0.753	84.6	62.8	55.53	89.09	70.09
CRP2 (mg/L)	98.00	0.651	56.4	71.8	50.00	76.71	66.67
WBC3 (× 109/L)	9.755	0.681	59.0	76.9	56.10	78.95	70.94
LDH3 (U/L)	255.96	0.724	41.0	94.9	80.00	76.28	76.92
CRP3 (mg/L)	101.00	0.754	69.2	74.4	57.45	82.65	72.65

AUC: Area under curve; PPV: Positive predictive value; NPV: Negative predictive value; MPV: Mean platelet volume; WBC: White blood cells; LDH: Lactate dehydrogenase; CRP: C-reactive protein.

Table 5 Mean platelet volume, white blood cells, lactate dehydrogenase and C-reactive protein on days 1, 2, 3 and 7 after admission in the non-severe acute pancreatitis and severe acute pancreatitis groups according to the 2012 revised Atlanta criteria

	Non-SAP group (n = 98)	SAP (n = 19)	t	P value
MPV1 (fL)	9.02 ± 2.27	7.19 ± 2.34	3.198	0.002
MPV2 (fL)	9.84 ± 2.30	8.77 ± 2.56	1.825	0.071
MPV3 (fL)	9.74 ± 1.88	9.92 ± 1.61	-0.387	0.699
MPV7 (fL)	10.39 ± 1.66	10.72 ± 1.67	-0.798	0.426
WBC1 (× 109/L)	12.85 ± 3.79	15.52 ± 3.36	-2.864	0.005
WBC2 (× 109/L)	10.95 ± 3.89	13.94 ± 5.08	-2.909	0.004
WBC3 (× 109/L)	8.81 ± 3.38	11.46 ± 3.02	-3.174	0.002
WBC7 (× 109/L)	7.22 ± 2.66	10.31 ± 4.05	-3.187	0.004
LDH1 (U/L)	238.82 ± 90.06	290.32 ± 82.45	-2.311	0.023
LDH2 (U/L)	196.39 ± 57.82	288.30 ± 125.57	-3.127	0.005
LDH3 (U/L)	193.37 ± 57.37	243.25 ± 95.41	-2.203	0.039
LDH7 (U/L)	190.58 ± 52.58	223.59 ± 61.12	-2.438	0.016
CRP1 (mg/L)	48.29 ± 79.96	63.05 ± 86.57	-0.726	0.469
CRP2 (mg/L)	84.56 ± 76.89	145.63 ± 125.27	-2.051	0.053
CRP3 (mg/L)	80.71 ± 68.79	181.58 ± 140.16	-3.066	0.006
CRP7 (mg/L)	29.96 ± 37.14	76.84 ± 68.26	-2.912	0.009

MPV: Mean platelet volume; WBC: White blood cells; LDH: Lactate dehydrogenase; CRP: C-reactive protein.

Table 6 Overall accuracy of mean platelet volume and other inflammation makers in predicting persistent organ failure on days 1, 2 and 3 after admission according to the 2012 revised Atlanta criteria

	Cut-off value	AUC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Overall accuracy (%)
MPV1 (fL)	6.65	0.716	91.8	47.4	52.49	70.00	67.52
WBC1 (× 109/L)	13.55	0.700	60.2	78.9	27.78	93.65	63.25
LDH1 (U/L)	239.08	0.697	73.7	62.2	27.45	92.42	64.10
WBC2 (× 109/L)	12.36	0.676	63.2	70.4	29.27	90.80	69.23
LDH2 (U/L)	263.28	0.740	52.6	86.7	43.48	90.43	81.20
CRP2 (mg/L)	63.50	0.667	78.9	49.0	38.46	92.31	53.00
WBC3 (× 109/L)	9.32	0.735	78.9	65.3	30.61	94.12	67.52
LDH3 (U/L)	260.87	0.655	42.1	89.7	44.44	88.89	82.05
CRP3 (mg/L)	206.50	0.749	42.1	95.9	66.67	89.52	87.17

AUC: Area under curve; PPV: Positive predictive value; NPV: Negative predictive value; MPV: Mean platelet volume; WBC: White blood cell; LDH: Lactate dehydrogenase; CRP: C-reactive protein.