Lei JJ, Zhou L, Liu Q, Xiong C, Xu CF. Can mean platelet volume play a role in evaluating the severity of acute pancreatitis? World J Gastroenterol 2017; 23(13): 2404-2413 [PMID: 28428720 DOI: 10.3748/wjg.v23.i13.2404]
Corresponding Author of This Article
Dr. Chun-Fang Xu, Professor, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. xcf601@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
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Lei JJ, Zhou L, Liu Q, Xiong C, Xu CF. Can mean platelet volume play a role in evaluating the severity of acute pancreatitis? World J Gastroenterol 2017; 23(13): 2404-2413 [PMID: 28428720 DOI: 10.3748/wjg.v23.i13.2404]
World J Gastroenterol. Apr 7, 2017; 23(13): 2404-2413 Published online Apr 7, 2017. doi: 10.3748/wjg.v23.i13.2404
Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?
Jing-Jing Lei, Li Zhou, Qi Liu, Can Xiong, Chun-Fang Xu
Jing-Jing Lei, Chun-Fang Xu, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Jing-Jing Lei, Li Zhou, Qi Liu, Can Xiong, Department of Gastroenterology, The Affiliated Baiyun Hospital of Guizhou Medical University, Guiyan 550014, Guizhou Province, China
Author contributions: Lei JJ, Zhou L and Xu CF designed the study; Lei JJ, Liu Q and Xiong C participated in the acquisition of the clinical data; Lei JJ, Zhou L and Xu CF participated in the analysis and interpretation of the data; Lei JJ drafted the initial manuscript; Xu CF was the guarantor and revised the article critically for important intellectual content.
Supported bythe Joint Foundation of Department of Science and Technology of Guizhou Province, China, No. [2016]7408.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, China.
Informed consent statement: All study participants or their legal guardian provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicting interests related to this study.
Data sharing statement: No additional data are available.
Correspondence to: Dr. Chun-Fang Xu, Professor, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. xcf601@163.com
Telephone: +86-512-67780357 Fax: +86-512-65228072
Received: December 4, 2016 Peer-review started: December 6, 2016 First decision: January 10, 2017 Revised: January 28, 2017 Accepted: February 17, 2017 Article in press: February 17, 2017 Published online: April 7, 2017 Processing time: 123 Days and 5 Hours
Core Tip
Core tip: Mean platelet volume (MPV) is a machine-calculated measurement of average platelet size that is easily obtained using automatic blood count equipment at no additional cost and is often overlooked by clinicians. However, the relationship between MPV and acute pancreatitis (AP) remains unclear, and previous studies have been limited and produced conflicting results. In the present study, we demonstrated that the MPV was significantly lower in AP patients than in controls during the first three days after admission, particularly on day 1 after admission. Moreover, on day 1 of hospital admission, white blood cell count, lactate dehydrogenase and C-reactive protein measures were not as sensitive as MPV for predicting persistent organ failure in AP patients.
