Full-thickness myotomy is associated with higher rate of postoperative gastroesophageal reflux disease

Table 1 Comparison of characteristics between the two groups

		Circular myotomy (n = 32)	Full-thickness myotomy (n = 24)	P value
Sex, M/F		13/19	11/13	0.315
Age (yr)		41.5 ± 10.8	44.5 ± 14.5	0.375
Disease course (yr)		5.3 ± 7.0	6.6 ± 8.4	0.535
Esophagus type, S/non-S		1/31	3/21	0.303
Previous therapy, Yes/No		6/26	5/19	0.846
Achalasia type, I/II/III		5/24/3	4/18/2	0.987
Pre-	Eckardt score	6.4 ± 1.3	6.5 ± 1.6	0.784
POEM	LESP, mmHg	39.5 ± 7.1	38.3 ± 6.0	0.502
	4sIRP, mmHg	28.4 ± 5.0	28.7 ± 5.3	0.849
Follow-up, mo		39.8 ± 4.2	38.6 ± 1.8	0.201
Post-	Eckardt score	0.47 ± 0.67	0.38 ± 0.65	0.602
POEM	LESP (mmHg)	14.6 ± 3.7	14.0 ± 3.0	0.500
	4sIRP (mmHg)	10.6 ± 2.8	10.2 ± 2.2	0.545
GERD symptoms		15.6% (5/32)	33.3% (8/24)	0.12
pH test +		40.6% (13/32)	50% (12/24)	0.485
Esophagitis (%)		15.6% (5/32)	29.2% (7/24)	0.222
Clinically relevant GERD		12.5% (4/32)	37.5% (9/24)	0.028

S/non-S: Sigmoid-type/non-sigmoid-type; GERD: Gastroesophageal reflux disease; pH test +: Abnormal esophageal acid exposure.

Table 2 Multivariate analyses for risk factors of clinically relevant gastroesophageal reflux disease

Item	B	SE	Sig	OR	95%CI of OR
Constant	8.810	3.261	0.007	0.000
Full-thickness myotomy	1.835	0.806	0.023	6.262	1.289, 30.413
Postoperative 4sIRP	0.769	0.299	6.628	2.158	1.202, 3.877

4sIRP: 4-s integrated relaxation pressure; OR: Odds ratio.