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©The Author(s) 2016.
World J Gastroenterol. Jun 21, 2016; 22(23): 5422-5429
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5422
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5422
Table 1 Correlation between endocan-microvessel density and clinicopathological features and vascular endothelial growth factor/vascular endothelial growth factor receptor 2 expression in gastric cancer
Clinicopathologic feature | n | Endocan-MVD | P value1 |
Gender | 0.27 | ||
Male | 93 | 18.19 ± 8.240 | |
Female | 49 | 19.79 ± 8.203 | |
Age (yr) | 0.32 | ||
< 60 | 78 | 19.36 ± 8.436 | |
≥ 60 | 64 | 18.00 ± 7.982 | |
Tumour size (cm) | 0.000a | ||
< 5 | 79 | 16.48 ± 9.170 | |
≥ 5 | 63 | 21.58 ± 5.799 | |
Borrmann type | 0.000a | ||
I | 18 | 11.33 ± 3.970 | |
II | 15 | 11.93 ± 4.651 | |
III | 81 | 21.17 ± 8.122 | |
IV | 28 | 20.14 ± 7.437 | |
Histology | 0.25 | ||
Adenocarcinoma | 118 | 19.11 ± 8.183 | |
Signet ring cell carcinoma | 8 | 16.55 ± 2.554 | |
Mixed carcinoma | 15 | 17.13 ± 10.602 | |
Differentiation | 0.000a | ||
High/moderate | 36 | 11.66 ± 4.623 | |
Low/undifferentiated | 106 | 21.15 ± 7.803 | |
Tumour invasion | 0.000a | ||
T1 | 2 | 6.33 ± 0.577 | |
T2 | 30 | 10.30 ± 4.822 | |
T3 | 4 | 16.33 ± 0.577 | |
T4 | 106 | 21.56 ± 7.168 | |
Lymph node metastasis | 0.000a | ||
N0 | 33 | 12.60 ± 7.314 | |
N1 | 21 | 17.521 ± 5.662 | |
N2 | 30 | 16.96 ± 7.420 | |
N3 | 58 | 23.62 ± 7.053 | |
TNM stage | 0.000a | ||
I | 15 | 8.80 ± 3.764 | |
II | 18 | 11.38 ± 5.679 | |
III | 99 | 20.85 ± 7.331 | |
IV | 10 | 26.10 ± 2.960 | |
VEGF expression | 0.001a | ||
Negative | 58 | 16.32 ± 6.227 | |
Positive | 84 | 20.43 ± 9.015 | |
VEGFR2 expression | 0.000a | ||
Negative | 66 | 12.48 ± 5.239 | |
Positive | 76 | 24.19 ± 6.222 |
Table 2 Correlation between endocan-microvessel density and vascular endothelial growth factor expression in gastric cancer (r = 0.167, P = 0.047), and between endocan-microvessel density and vascular endothelial growth factor receptor 2 expression in gastric cancer (r = 0.410, P = 0.000)
Table 3 Univariate analysis of the correlation between clinicopathologic features and overall survival of 142 patients with gastric cancer
Clinicopathologic feature | n | 5-yr survival rate (%) | P value1 |
Gender | 0.280 | ||
Male | 93 | 44.08 | |
Female | 49 | 38.77 | |
Age (yr) | 0.580 | ||
< 60 | 78 | 41.02 | |
≥ 60 | 64 | 43.75 | |
Tumour size (cm) | 0.000a | ||
< 5 | 79 | 62.02 | |
≥ 5 | 63 | 17.46 | |
Borrmann type | 0.000a | ||
I + II | 33 | 78.78 | |
III + IV | 109 | 31.19 | |
Histology | 0.260 | ||
Adenocarcinoma | 118 | 40.67 | |
Others | 23 | 52.17 | |
Differentiation | 0.000a | ||
High/moderate | 36 | 69.44 | |
Low/undifferentiated | 106 | 33.01 | |
Tumour invasion | 0.000a | ||
T1-2 | 32 | 84.37 | |
T3-4 | 110 | 30.00 | |
Lymph node metastasis | 0.003a | ||
N0-1 | 54 | 57.40 | |
N2-3 | 88 | 32.95 | |
TNM stage | 0.000a | ||
I-II | 33 | 84.84 | |
III-IV | 109 | 29.35 | |
VEGF expression | 0.003a | ||
Negative | 58 | 56.89 | |
Positive | 84 | 32.14 | |
VEGFR2 expression | 0.000a | ||
Negative | 66 | 68.18 | |
Positive | 76 | 19.73 | |
Endocan-MVD | 0.000a | ||
Low | 75 | 64.00 | |
High | 67 | 17.91 |
Table 4 Multivariate analysis of the correlation between clinicopathologic features and overall survival of 142 patients with gastric cancer
Factor | P value | HR | 95%CI |
Tumour size (cm) | 0.247 | 1.407 | 0.789-2.508 |
Borrmann type | 0.388 | 1.345 | 0.686-2.636 |
Differentiation | 0.036a | 3.52 | 1.087-11.394 |
Tumour invasion | 0.681 | 1.465 | 0.237-9.066 |
Lymph node metastasis | 0.75 | 1.119 | 0.560-2.235 |
TNM stage | 0.000a | 4.189 | 1.450-12.102 |
VEGF expression | 0.001a | 2.827 | 1.508-5.302 |
VEGFR2 expression | 0.020a | 3.572 | 1.218-10.474 |
High endocan-MVD | 0.047a | 2.111 | 1.008-4.419 |
- Citation: Chang Y, Niu W, Lian PL, Wang XQ, Meng ZX, Liu Y, Zhao R. Endocan-expressing microvessel density as a prognostic factor for survival in human gastric cancer. World J Gastroenterol 2016; 22(23): 5422-5429
- URL: https://www.wjgnet.com/1007-9327/full/v22/i23/5422.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i23.5422