Gut microbiota imbalance and colorectal cancer

doi:10.3748/wjg.v22.i2.501

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2016; 22(2): 501-518
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501

Table 1 Summary of 16S rRNA sequencing and qPCR analyses of colonic microbiota variations in colorectal cancer

Variation in CRC	Phyla	Genus/species	Population	Ref.
Fecal flora
↑		Enterococcus Faecalis	20 CRC/17 C	[73]
↑	Proteobacteria	Porphyromonas/Escherichia/Shigella Enterococcus/Streptococcus/Peptostreptococcus	46 CRC/56 C	[62]
↑	Proteobacteria	Bacteroides fragilis	46 CRC/56 C	[62]
↑		Bacteroides/Prevotella	60 CRC/119 C	[61]
↑		Peptostreptococcus/Mogibacterium	21 CRC/22 C	[18]
		Anaerococcus/Slakia/Paraprevotella
		Anaerotruncus/Collinsella/Desulfovibrio
		Eubacterium/Porphyromonas
↑	Bacteroidetes	Atopobium/Porphyromonas	47 CRC/94 C	[63]
↑	Fusobacteria	Fusobacterium	47 CRC/94 C	[63]
↑	Fusobacteria	Fusobacterium/Bacteroides	19 CRC/20 C	[64]
↑		Bacteroides/Fusobacterium	46 CRC/63 C	[214]
↑		Alistipes/Escherichia/Parvimonas/Bilophila	46 CRC/63 C	[214]
↓		Faecalibacterium prauznitsii	20 CRC/17 C	[73]
↓	Bacteroidetes	Bacteroides vulgatus/Bacteroides uniformis	46 CRC/56 C	[62]
↓	Bacteroidetes	Roseburia/Butyrate-producing bacteria	46 CRC/56 C	[62]
↓		Faecalibacterium prauznitsii/Roseburia	19 CRC/20 C	[64]
↓	Firmicutes (clostridia)	Ruminococcus	47 CRC/94 C	[63]
↓		Ruminococcus/Bifidobacterium/Streptococcus	46 CRC/63 C	[214]
Tumor-associated flora
↑	Bacteroidetes	Coriobacteriae/Roseburia	6 CRC/6 AM	[14]
		Fusobacterium/Faecalibacterium
		Butyrate-producing bacteria
↑		Bacteroides	22 CRC/22 C	[61]
↑		Fusobacterium	95 CRC'95 AM	[106]
↑	Bacteroidetes	Bacteroides/Prevotella/Streptococcus	27 CRC	[18]
	Fusobacteria	Fusobacterium/Peptostreptococcus	27 intestinal lumen
	Proteobacteria	Morganella/Porphyromonas	27 intestinal lumen
↑		Fusobacterium	55 CRC/55 AM	[109]
↓	Firmicutes	Shigella/Citrobacter/Serratia/Salmonella	6 CRC/6 AM	[14]
↓	Firmicutes	Lactobacillus/Roseburia/Pseudobutyrivibrio	27 CRC	[18]
↓	Firmicutes	Lactobacillus/Roseburia/Pseudobutyrivibrio	27 intestinal lumen	[18]
↓	Bacteroidetes		95 CRC/95 AM	[106]
↓	Firmicutes (clostridia)		95 CRC/95 AM	[106]
Mucosa-associated flora
↑		Fusobacterium/Porphyromonas	32 CRC	[18]
		Peptostreptococcaceae/Gemella	22 C (swab)	[18]
		Mogibacterium/Klebsiella	22 C (swab)
↓		Faecalibacterium/Blautia/Anaeroslipes	32 CRC	[18]
↓		Lachospira/Bifidobacterium	22 C (swab)	[18]

CRC: Colorectal cancer; C: Control patients; AM: Adjacent tumor, normal mucosa of patients with CRC.

Citation: Gagnière J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E, Bringer MA, Pezet D, Bonnet M. Gut microbiota imbalance and colorectal cancer. World J Gastroenterol 2016; 22(2): 501-518
URL: https://www.wjgnet.com/1007-9327/full/v22/i2/501.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i2.501