Topic Highlight
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2016; 22(2): 501-518
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
Gut microbiota imbalance and colorectal cancer
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet, Clermont Université, UMR 1071 Inserm/Université d’Auvergne, 63000 Clermont-Ferrand, France
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet, INRA, USC-2018, 63000 Clermont-Ferrand, France
Johan Gagnière, Julie Veziant, Emmanuel Buc, Denis Pezet, Chirurgie Digestive, Centre Hospitalier Universitaire, 63000 Clermont-Ferrand, France
Richard Bonnet, Bactériologie, Centre Hospitalier Universitaire, 63000 Clermont-Ferrand, France
Jennifer Raisch, Laboratoire d’Immunologie, Institut Armand Frappier, Laval H7V 1B7, Canada
Marie-Agnès Bringer, INRA UMR 1324, CNRS UMR 6265, Université de Bourgogne, Centre des Sciences du Goût et de l’Alimentation, Eye Nutrition and Signalling Research Group, 21000 Dijon, France
Author contributions: Gagnière J, Raisch J and Veziant J organized and wrote the manuscript; Barnich N, Bonnet R, Buc E, Bringer MA and Pezet D supervised the writing of the manuscript; Bonnet M organized, wrote and supervised the writing and the manuscript.
Supported by Inserm and Université d’Auvergne (UMR 1071), INRA (USC-2018); and grants from “Conseil regional d’Auvergne”, “Nuovo Soldati Foundation for Cancer Research” and “Fondation pour la recherche médicale”.
Conflict-of-interest statement: None of the authors have any conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mathilde Bonnet, PhD, M2iSH “Microbes, intestin, inflammation et Susceptibilité de l’Hôte” UMR 1071 Inserm/Université d’Auvergne USC INRA 2018, Centre Biomédical de Recherche et Valorisation, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France. mathilde.bonnet@udamail.fr
Telephone: +33-4-7318381 Fax: +33-4-73178371
Received: April 28, 2015
Peer-review started: May 6, 2015
First decision: August 25, 2015
Revised: September 6, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: January 14, 2016
Processing time: 253 Days and 11.6 Hours
Core Tip

Core tip: The gut microbiota acts as a real organ and many changes in its composition have been reported in colorectal cancer. The pro-carcinogenic properties of bacteria are now better understood. In this review, we discuss possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on the dysbiosis-causing and pro-carcinogenic properties of bacteria, such as genotoxicity, inflammation, and oxidative stress. We lastly detail how microbiota modifications may represent novel prognosis markers and/or targets for innovative therapeutic strategies.