Survival analysis of cholangiocarcinoma: A 10-year experience in Malaysia

Table 1 Laboratory data on admission and location of tumours

	Total	Intrahepatic	Perihilar	Distal	P
	(n = 69)	(n = 12)	(n = 38)	(n = 19)	value1
Total bilirubin (mmol/L)	178 (158)	45 (109)	216 (163)	188 (131)	0.003
Conjugated bilirubin (mmol/L)	140 (122)	31 (87)	170 (123)	151 (102)	0.002
INR	1.2 (0.7)	1.1 (0.1)	1.0 (0.1)	1.6 (1.1)	0.005

¹Analysis of variance. Values in mean (SD); P value < 0.05 is significant. INR: International normalized ratio.

Table 2 Types of surgical resection

Types of surgery	Patients (n = 12)
Left hemihepatectomy	2
Right hemihepatectomy	1
Segmental hepatic resections	2
Extrahepatic bile duct resection	5
Whipple’s procedure	2

Table 3 Tumour histology, degree of differentiation, diameter, margin, perineural and lymph node involvements by tumour location n (%)

	Total	Intrahepatic	Perihilar	Distal	P
	(n = 12)	(n = 3)	(n = 6)	(n = 3)	value1
Tumour histology
Adenocarcinoma	11 (92)	2 (18%)	6 (55%)	3 (27)
Other	1 (8)	1 (100%)	0	0
Degree of differentiation
Well	5 (42)	2 (40%)	2 (40%)	1 (20)
Moderate	6 (50)	1 (17%)	3 (50%)	2 (34)
Poor	1 (8)	0	1 (100%)	0
Tumour diameter, cm
Size, mean ± SD	9.6 ± 15.2	27.1 ± 24.3	2.8 ± 2.2	5.7 ± 15.2	0.0481
Margin
Negative	7 (58)	3 (43)	3 (43)	1 (14)
Positive	5 (42)	0	3 (60)	2 (40)
Lymph node involvement
Negative	8 (67)	2 (25)	4 (50)	2 (25)
Positive	4 (33)	1 (25)	2 (50)	1 (25)
Perineural involvement
Negative	5 (42)	3 (60)	2 (40)	0
Positive	7 (58)	0	4 (57)	3 (43)
Lymphovascular invasion
Negative	7 (58)	2 (29)	4 (57)	1 (14)
Positive	5 (42)	1 (20)	2 (40)	2 (40)

¹Analysis of variance. P value < 0.05 is significant.

Table 4 Univariate analysis of different variables in relation to survival

Variables	Survival rates (%)			P value
	1-year	2-year	3-year
Jaundice				0.038
Absent	40	19	9
Present	19	6	2
Staging				0.016
Stage 1	43	17	9
Stage 2	43	14	0
Stage 3	12	4	0
Stage 4	5	0	0
Surgery (curative or palliative)				0.017
No	13	10	0
Yes	45	9	9
Curative resection				0.002
No	14	8	0
Yes	67	17	17
Type (among resected patient)				0.003
Intrahepatic	100	33	33
Perihilar	67	17	17
Distal	33	0	0
Type (among all patient)				0.027
Intrahepatic	50	23	11
Perihilar	18	6	3
Distal	16	5	0
Histology				0.032
Well	80	40	40
Moderate and poor	57	0	0
Margin involvement				0.013
Negative	86	29	29
Positive	40	0	0