Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy

Table 1 Baseline characteristics of patients in two groups

Operative procedure	Vagus nerve preservation (n = 9)	Vagotomy (n = 7)	P
Age (yr)	59.01 ± 13.12	52.74 ± 6.40	NS
Sex (male/female)	6/3	4/3	NS
Body weight (kg)	62.01 ± 11.22	63.13 ± 6.01	NS
BMI (kg/m2)	23.21 ± 2.40	24.41 ± 3.53	NS
TNM stage			NS
II	5 (55.5)	3 (42.8)
IIIa	4 (45.5)	4 (57.2)
Pathologic type			NS
Differentiated	6 (66.6)	4 (57.2)
Undifferentiated	3 (33.4)	3 (42.8)
Reconstruction			NS
Billroth-1	5 (55.5)	5 (71.4)
Roux-en-Y	4 (45.5)	2 (28.6)
Laboratory values
Peptide YY3-36 (ng/mL)	0.38 ± 0.10	0.42 ± 0.07	NS
Ghrelin (pg/mL)	693.71 ± 211.25	703.90 ± 238.89	NS
Leptin (ng/mL)	3.88 ± 4.59	5.50 ± 7.99	NS
Insulin (mIU/L)	6.36 ± 3.95	6.47 ± 4.66	NS
Growth hormone (ng/mL)	1.51 ± 2.34	1.4 ± 0.18	NS
HOMA index	1.70 ± 1.24	1.68 ± 1.38	NS
Albumin (g/dL)	3.71 ± 0.43	3.63 ± 0.52	NS
Total protein (g/dL)	6.93 ± 0.50	6.92 ± 1.04	NS
Total cholesterol (mg/dL)	204.91 ± 25.23	209.63 ± 21.11	NS
Triglyceride (mg/dL)	171.72 ± 49.21	140.41 ± 45.24	NS

Data were expressed as mean ± SD or n (%). BMI: Body mass index; TNM: Tumor, node, metastasis; HOMA: Homeostatic model assessment; NS: Not significant.

Table 2 Changes of body weight, body mass index and laboratory values between pre-operation and one month after operation and parameters at 1 mo after operation in two groups

	Changes from pre-operation to one month after operation			One month after operation
Operative procedure	Vagus nerve preservation (n = 9)	Vagotomy (n = 7)	P	Vagus nerve preservation (n = 9)	Vagotomy (n = 7)	P
Body weight (kg)	-5.56 ± 2.24	-7.85 ± 1.57	0.0371	56.44 ± 10.40	55.29 ± 4.99	NS
BMI (kg/m2)	-1.91 ± 1.04	-2.91 ± 0.39	0.0312	21.21 ± 2.08	21.44 ± 3.39	NS
Peptide YY3-36 (ng/mL)	0.06 ± 0.08	0.19 ± 0.12	0.0213	0.44 ± 0.07	0.62 ± 0.17	0.0204
Ghrelin (pg/mL)	-229.23 ± 196.69	-174.47 ± 174.58	NS	464.47 ± 235.49	529.43 ± 134.86	NS
Leptin (ng/mL)	-2.08 ± 3.38	-3.56 ± 7.41	NS	1.79 ± 1.31	1.94 ± 1.79	NS
Insulin (mIU/L)	9.5 ± 12.37	11.01 ± 8.26	NS	15.86 ± 10.89	17.48 ± 7.48	NS
HOMA index	0.33 ± 0.15	0.35 ± 0.43	NS	2.10 ± 1.79	2.25 ± 1.99	NS
Growth hormone (ng/mL)	0.07 ± 3.32	0.19 ± 0.12	NS	1.58 ± 2.20	1.95 ± 2.44	NS
Albumin (g/dL)	-0.05 ± 0.32	-0.14 ± 0.66	NS	3.64 ± 0.31	3.50 ± 0.43	NS
Total protein (g/dL)	-0.17 ± 0.71	-0.18 ± 0.83	NS	6.77 ± 0.41	6.78 ± 0.88	NS
Total cholesterol (mg/dL)	-4.00 ± 15.21	-6.57 ± 10.42	NS	200.88 ± 22.31	203.00 ± 27.82	NS
Triglyceride (mg/dL)	-14.33 ± 20.40	-11.71 ± 18.93	NS	157.44 ± 38.29	128.71 ± 36.66	NS

All data were expressed as mean ± SD.

¹95% confidence interval (CI) = -4.445 to -0.157;

²95% CI = -1.902 to -0.103;

³95% CI = -0.224 to -0.022;

⁴95% CI = -0.320 to -0.032. BMI: Body mass index; HOMA: Homeostatic model assessment; NS: Not significant.