Kim HH, Park MI, Lee SH, Hwang HY, Kim SE, Park SJ, Moon W. Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy. World J Gastroenterol 2012; 18(30): 4044-4050 [PMID: 22912556 DOI: 10.3748/wjg.v18.i30.4044]
Corresponding Author of This Article
Moo In Park, MD, Department of Internal Medicine, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-702, South Korea. mipark@ns.kosinmed
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Brief Article
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World J Gastroenterol. Aug 14, 2012; 18(30): 4044-4050 Published online Aug 14, 2012. doi: 10.3748/wjg.v18.i30.4044
Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy
Hyung Hun Kim, Moo In Park, Sang Ho Lee, Hyun Yong Hwang, Sung Eun Kim, Seun Ja Park, Won Moon
Hyung Hun Kim, Moo In Park, Sung Eun Kim, Seun Ja Park, Won Moon, Departments of Internal Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
Sang Ho Lee, Departments of Surgery, Kosin University College of Medicine, Busan 602-702, South Korea
Hyun Yong Hwang, Departments of Laboratory Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
Author contributions: Kim HH performed statistical analysis and wrote this paper as the first author; Park MI designed this study and reviewed this paper as a corresponding author; Lee SH performed operation in all patients enrolled in this study; Hwang HY was responsible for measuring hormones and other laboratory values; and Kim SE, Park SJ and Moon W supported the analysis of results and discussion.
Correspondence to: Moo In Park, MD, Department of Internal Medicine, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-702, South Korea. mipark@ns.kosinmed
Telephone: +82-51-9905205 Fax: +82-51-9905055
Received: January 15, 2012 Revised: March 15, 2012 Accepted: April 9, 2012 Published online: August 14, 2012
Abstract
AIM: To investigate the relationship between the function of vagus nerve and peptide YY3-36 and ghrelin levels after subtotal gastrectomy.
METHODS: We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer. All surgeries were performed by a single skilled surgeon. We measured peptide YY3-36, ghrelin, leptin, insulin, growth hormone levels, and body weight immediately before and one month after surgery.
RESULTS: Vagus nerve preservation group showed less body weight loss and less increase of peptide YY3-36 compared with vagotomy group (-5.56 ± 2.24 kg vs -7.85 ± 1.57 kg, P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL, P = 0.021, respectively). Moreover, patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY3-36 level, typically less than 20% [6 (66.7%) vs 0 (0.0%), P = 0.011, odd ratio = 3.333, 95% confidence interval (1.293, 8.591)].
CONCLUSION: Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy, and this phenomenon may be related to the suppressed activity of peptide YY3-36.
