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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 28, 2011; 17(36): 4113-4117
Published online Sep 28, 2011. doi: 10.3748/wjg.v17.i36.4113
Published online Sep 28, 2011. doi: 10.3748/wjg.v17.i36.4113
Table 1 Distribution of -1195 G/A and -765 G/C COX-2 genotype in the analyzed group of patients n (%)
| Genotype | PC patients(n = 85) | Control group(n = 116) | OR (95% CI) |
| -1195 G/A | |||
| GG | 13 (15.7) | 44 (37.9) | Reference |
| GA | 26 (30.6) | 48 (41.4) | 1.83 (0.84-4.00) |
| AA | 46 (53.7) | 24 (21.0) | 6.48 (2.93-14.31) |
| - 765 G/C | |||
| GG | 47 (55.4) | 44 (37.9) | Reference |
| GC | 27 (31.7) | 40 (34.5) | 0.63 (0.33-1.19) |
| CC | 11 (12.9) | 32 (27.6) | 0.32 (0.14-1.71) |
Table 2 Relationship between -1195 G/C COX-2 polymorphism and clinical data of patients with pancreatic cancer n (%)
| Group | G+ allele(GA and GG)(n = 39) | P value | G- allele(AA)(n = 46) | P value | |
| Age | < 65 | 20 (51.3) | NS | 19 (41.3) | NS |
| ≥ 65 | 19 (48.7) | 27 (58.7) | |||
| Gender | Male | 18 (46.2) | NS | 23 (50.0) | NS |
| Female | 21 (53.8) | 23 (50.0) | |||
| Tumor size | ≤ 3 cm | 21 (53.8) | NS | 13 (28.3) | P < 0.05 |
| > 3 cm | 18 (46.2) | 33 (71.7) | |||
| Tumor | G1 + G2 | 21 (53.8) | NS | 27 (58.7) | NS |
| Differentiation | G3 | 17 (43.8) | 18 (39.2) | ||
| Lymph node | Absent | 23 (58.9) | NS | 23 (50.0) | NS |
| Metastases | Present | 16 (41.1) | 23 (50.5) | ||
| Weight loss | < 10 % | 19 (48.7 | NS | 25 (54.4) | NS |
| ≥ 10% | 20 (51.3) | 21 (45.6) | |||
| Smoking | Yes | 21 (53.8) | NS | 19 (41.3) | NS |
| No | 18 (46.2) | 27 (58.7) | |||
| CA19-9 | < 37 U/mL | 10 (25.6) | NS | 13 (28.3) | NS |
| ≥ 37 U/mL | 29 (74.4) | 33 (71.7) |
Table 3 Relationship between -765 G/C COX-2 polymorphism and clinical data of patients with pancreatic cancer n (%)
| Group | G+ allele(GC and GG)(n = 47) | P value | G- allele(CC)(n = 38) | P value | |
| Age | < 65 | 23 (48.9) | NS | 16 (42.1) | NS |
| ≥ 65 | 24 (51.1) | 22 (57.9) | |||
| Gender | Male | 22 (46.8) | NS | 19 (50.0) | NS |
| Female | 25 (53.2) | 19 (50.0) | |||
| Tumor size | ≤ 3 cm | 17 (40.4) | NS | 15 (39.5) | NS |
| > 3 cm | 28 (59.6) | 23 (60.5) | |||
| Tumor | G1 + G2 | 27 (57.4) | NS | 21 (55.3) | NS |
| Differentiation | G3 | 20 (40.4) | 16 (42.1) | ||
| Lymph node | Absent | 28 (59.8) | NS | 18 (47.4) | NS |
| Metastases | Present | 19 (40.4) | 20 (52.6) | ||
| Weight loss | < 10 % | 30 (63.8) | NS | 21 (55.3) | NS |
| ≥ 10% | 17 (36.2) | 17 (44.7) | |||
| Smoking | Yes | 23 (48.9) | NS | 17 (44.7) | NS |
| No | 24 (51.1) | 21 (55.3) | |||
| CA19-9 | < 37 U/mL | 12 (25.5) | NS | 12 (31.6) | NS |
| ≥ 37 U/mL | 35 (74.5) | 26 (68.4) |
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Citation: Talar-Wojnarowska R, Gasiorowska A, Olakowski M, Lampe P, Smolarz B, Romanowicz-Makowska H, Malecka-Panas E. Role of
cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis. World J Gastroenterol 2011; 17(36): 4113-4117 - URL: https://www.wjgnet.com/1007-9327/full/v17/i36/4113.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i36.4113