Portal vein thrombosis and arterioportal shunts: Effects on tumor response after chemoembolization of hepatocellular carcinoma

Table 1 Patient and tumor criteria (n)

Total number	39
Age (yr)	Range: 45-79, mean: 66.4, SD: 7
Gender (M:F)	33:6
Underlying liver pathology
Hepatitis C virus	17
Hepatitis B virus	5
Alcoholic cirrhosis	7
Toxic cirrhosis	2
Cryptogenic cirrhosis	8
Child-Pugh Score
Child A	27
Child B	12
Tumor number
Solitary	20
Multiple	19
2 lesions	6
3 lesions	3
4 lesions	1
> 5 lesions	9
Tumor margin definition
Well defined margin	20
Ill defined margin	19
Portal vein thrombosis	19
Main (partial thrombosis)	3
Main lobar branch	10
Segmental branch	6
A-P shunt	7

Table 2 Response evaluation criteria in solid tumors in different patient groups n (%)

	Total	B		APS		Child A	Child B	Solitary	Multiple	Well defined	Ill defined
		Yes	No	Yes	No
No. of patients	39	19	20	7	32	27	12	20	19	20	19
Partial response	1 (2.6)	0	1 (5)	0	1 (3.1)	0	1 (8.3)	0	1 (5.2)	1 (5)	0
Stable disease	34 (87.1)	18 (94.7)	16 (80)	6 (85.7)	28 (87.5)	24 (88.9)	10 (83.3)	18 (90)	16 (84.2)	17 (85)	17 (89.4)
Progressive disease	4 (10.3)	1 (5.3)	3 (15)	1 (14.2)	3 (9.30)	3 (11.1)	1 (8.3)	2 (10)	2 (10.5)	2 (10)	2 (10.5)

PVT: Portal vein thrombosis; APS: Arterioportal shunt.

Table 3 Magnetic resonance imaging volumetric changes of tumors after transarterial chemoembolization in different patient groups

	Total	PVT		APS		Child A	Child B	Solitary	Multiple	Well defined	Ill defined
		Yes	No	Yes	No
No. of patients	39	19	20	7	32	27	12	20	19	20	19
Initial tumor volume (mL)
Range	1.2-1358	1.2-1358	28.8-301.9	28.9-237	1.2-1358	1.1-1355	56.7-1358	1.2-1355	23.4-1358	1.2-301.9	28.8-1358
Mean	227.6	354.5	107	109.2	253.5	162.3	374.5	246	208.2	97.0	365
SD	318.76	418.2	78.5	75.2	345.8	275.8	370.5	317	327.2	60.0	411
Tumor volume 1 mo after the 1st TACE
Range	1.3-1637.5	1.3-1637.5	15.6-334.8	39-239	1.3-637.5	1.3-1500	23.7-1637.5	1.3-1499.7	15.6-1637.5	1.3-334.9	39-1637.5
Mean	244.5	402.6	94.3	126.5	270.3	159.6	435.6	242.6	246.6	65.3	412
SD	369	480.1	72.8	85.0	402.2	284.7	470.0	334.3	411.9	75.3	473
Tumor volume at the end of treatment
Range	1.6- 2053.4	1.6-2053.4	9.4-403.1	94.5-308	1.6-2053.4	1.6-2053.4	22.5-1637.5	1.6-2053.4	9.4-1637.4	1.6-403.1	83-2053.4
Mean	286.1	486	96.2	188.6	307.5	197.4	485.6	280.8	291.7	74.3	509.1
SD	453.2	583.7	100	72.5	490	391	534.2	452.9	465.8	69.5	568

PVT: Portal vein thrombosis; APS: Arterioportal shunt; TACE: Transarterial chemoembolization

Table 4 Local tumor response using volumetric magnetic resonance imaging analysis n (%)

	Total	PVT		APS		Child A	Child B	Solitary	Multiple	Well defined	Ill defined
		Yes	No	Yes	No
No. of patients	39	19	20	7	32	27	12	20	19	20	19
Tumor volume reduction after last TACE session	17 (43.6)	5 (26.3)	12 (60)	0 (0)	17 (53.1)	13 (48.1)	4 (33.3)	9 (45)	8 (42.1)	13 (65)	4 (21.05)
Tumor volume progression after last TACE session	22 (56.4)	14 (73.7)	8 (40)	7 (100)	15 (46.9)	14 (51.9)	8 (66.7)	11 (55)	11 (57.9)	7 (35)	15 (78.9)

PVT: Portal vein thrombosis; APS: Arterioportal shunt; TACE: Transarterial chemoembolization