Carcinoma of the middle bile duct: Is bile duct segmental resection appropriate?

Table 1 Univariate analysis of the predictors for survival of the 45 patients who underwent radical BDSR for PBD-1 or MBD disease

Characteristic	Number of patients	Median survival time (mo)	Survival rate (%)		P-value
			3-yr	5-yr
Overall	45	25	51.7	36.6
Age (yr)					0.466
≤ 65	25	42	56.4	38.7
> 65	20	33	45.5	34.1
Gender					0.314
Male	30	35	47	28.2
Female	15	42	58.2	48.5
CA19-9 (U/mL)					0.519
≤ 35	19	42	51.6	25.8
> 35	19	55	61.5	49.2
No data	7
Bilirubin at admission (mg/dL)					0.368
≤ 1.6	11	NR	53.3	53.3
> 1.6	34	42	50.5	34.1
Bilirubin at operation (mg/dL)					0.149
≤ 1.6	17	55	65.5	43.6
> 1.6	28	29	43.7	31.9
Preoperative biliary drainage					0.632
No	10	35	40	0.0
Yes	35	42	53.8	42.3
Location					0.547
MBD	34	42	51.4	44.1
PBD-1	11	52	51.9	26
LN dissection					0.997
D1	8	42	58.3	29.2
D2	37	52	51.2	42.6
Transfusion					0.832
No	36	42	51.2	39.4
Yes	9	33	47.6	23.8
Size (cm)					0.892
≤ 2.0	26	35	47	39.2
> 2.0	19	52	56.6	33.9
T stage					< 0.001
T1	9	NR	100	100
T2	33	35	49.6	31.5
T3	3	16	0.0	0.0
LN stage					0.010
N0	32	52	63.1	42.6
N1	13	25	19.2	19.2
TNM stage					0.012
Ia	9	NR	100	100
Ib	23	42	55.8	32.6
IIb	13	25	19.2	19.2
Cell differentiation					0.005
Well	15	NR	87.5	57.5
Moderate	26	33	41.6	33.3
Poor	4	22	0.0	0.0
Perineural invasion					0.180
No	13	NR	71.1	71.1
Yes	32	35	47.7	29.8

BDSR: Bile duct segmental resection; CA19-9: Carbohydrate antigen 19-9; MBD: Middle bile duct cancer; PBD-1: Proximal bile duct cancers; LN: Lymph node; NR: Not reached.

Table 2 The clinical characteristics of the BDSR group were compared with the PD group n (%)

Characteristics	BDSR group	PD group
Total patients	45	149
Age (median, yr)	65 (37-76)	60 (31-78)
Gender
Male	30 (66.7)	102 (68.5)
Female	15 (33.3)	47 (31.5)
Median follow-up (mo)	25.0 (4.0-104.0)	21.9 (0.4-108.5)
T stage
T1	9 (20.0)	32 (21.4)
T2	33 (73.3)	20 (13.4)
T3	3 (6.7)	90 (60.5)
T4	0 (0.0)	7 (4.7)
N status
N0	32 (71.2)	101 (67.8)
N1	13 (28.8)	48 (32.2)
TNM stage
Ia	9 (20.0)	24 (16.1)
Ib	23 (51.1)	15 (10.1)
IIa	0 (0.0)	58 (38.9)
IIb	13 (28.9)	44 (29.5)
III	0 (0.0)	8 (5.4)

PD: Pancreaticoduodenectomy.