Clinical Research
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2007; 13(27): 3714-3720
Published online Jul 21, 2007. doi: 10.3748/wjg.v13.i27.3714
Table 1 Tests for K-ras, p53 and p16 mutations, and LOH at chromosome 9p (site of p16 gene) and LOH at chromosome 18q (site of DPC4 gene) n (%)
ChronicpanceratitisPancreaticcancerTotalSensitivity(95% CI)Specificity(95% CI)PYouden'sindex
K-rasNegative20 (100)24 (29.6)44 (43.6)70%100%< 0.00170%
Positive0 (0)57 (70.4)57 (56.4)(60%-80%)
Total20 (100)81 (100)101 (100)
p53Negative18 (90)62 (76.5)80 (79.2)24%90%0.18 (NS)14%
Positive2 (10)19 (23.5)21 (20.8)(14%-34%)(85%-95%)
Total20 (100)81 (100)101 (100)
p16Negative20 (100)70 (87.5)90 (90)13%100%0.096 (NS)13%
Positive0 (0)10 (12.5)10 (10)(7%-19%)
Total20 (100)80 (100)100 (100)
LOH 9pNegative9 (64.3)8 (15.4)17 (25.8)85%64%< 0.00149%
Positive5 (35.7)44 (84.6)49 (74.2)(75%-95%)(53%-75%)
Total14 (100)52 (100)66 (100)
LOH 18qNegative8 (57.1)11 (22.4)19 (30.2)78%57%< 0.0535%
Positive6 (42.9)38 (77.6)44 (69.8)(67%-89%)(45%-69%)
Total14 (100)49 (100)63 (100)
Table 2 Combination of test for various molecular markers
Combination of tests95% CIPYouden'sindex
K-ras + LOH 9pSensitivity92%85%-99%< 0.00157%
Specificity64%53%-75%
K-ras + LOH 18qSensitivity92%85%-99%< 0.00149%
Specificity57%45%-69%
LOH 9p + LOH 18qSensitivity92%85%-99%< 0.0134%
Specificity43%31%-55%
p16 + LOH 9pSensitivity84%74%-94%< 0.00149%
Specificity64%53%-75%
K-ras + p53Sensitivity74%65%-83%< 0.00164%
Specificity90%85%-95%
K-ras + LOH 9pSensitivity96%92%-100%< 0.00139%
+ LOH 18qSpecificity43%31%-55%
K-ras + p16Sensitivity92%85%-99%< 0.00157%
+ LOH 9pSpecificity64%53%-75%
p53 + LOH 9pSensitivity92%85%-99%< 0.00135%
+ LOH 18qSpecificity43%31%-55%

  • Citation: Salek C, Benesova L, Zavoral M, Nosek V, Kasperova L, Ryska M, Strnad R, Traboulsi E, Minarik M. Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. World J Gastroenterol 2007; 13(27): 3714-3720
  • URL: https://www.wjgnet.com/1007-9327/full/v13/i27/3714.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v13.i27.3714