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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2007; 13(26): 3614-3618
Published online Jul 14, 2007. doi: 10.3748/wjg.v13.i26.3614
Published online Jul 14, 2007. doi: 10.3748/wjg.v13.i26.3614
Table 1 Demographic data (means ± SD)
NASH(n = 30) | Control(n = 30) | P-value | |
Mean age (yr) | 53.7 (7.0) | 51.0 (6.7) | |
Female (n, %) | 25 (83.3) | 26 (86.7) | |
Systolic blood pressure (mmHg) | 137.8 (15.6) | 123.4 (16.5) | 0.001 |
Diastolic blood pressure (mmHg) | 81.6 (7.5) | 77.1 (9.7) | 0.048 |
Body mass index (BMI) (kg/m2) | 27.7 (3.9) | 23.9 (3.3) | < 0.001 |
BMI classification1 (n, %) | |||
Normal | 2 (6.7) | 12 (40) | < 0.001 |
Pre-obesity | 2 (6.7) | 8 (26.7) | |
Obesity classI | 18 (60) | 9 (30) | |
Obesity class II | 8 (26.7) | 1 (3.3) | |
Triceps skin fold (mm) | 28.9 (6.0) | 25.0 (6.5) | 0.02 |
Waist circumference (cm) | 89.1 (8.9) | 76.4 (8.0) | < 0.001 |
Waist to hip ratio | 0.87 (0.1) | 0.81 (0.1) | < 0.001 |
Fat mass (kg) | 21.2 (5.1) | 15.8 (4.5) | < 0.001 |
Abdominal fat (x 103, g) | 6.0 (1.4) | 3.8 (1.5) | < 0.001 |
Visceral fat area (cm2) | 147.8 (38.7) | 92.9 (29.9) | < 0.001 |
Subcutaneous fat area (cm2) | 272.2 (85.1) | 189.7 (64.9) | < 0.001 |
Visceral to total fat ratio | 0.36 (0.09) | 0.34 (0.10) | |
Visceral to subcutaneous fat ratio | 0.60 (0.23) | 0.55 (0.33) |
Table 2 Biochemical tests (means ± SD)
NASH | Control | P-value | |
AST (IU/L) | 70.9 (40.4) | 19.9 (5.6) | < 0.001 |
ALT (IU/L) | 116.1 (45.2) | 35.2 (9.7) | < 0.001 |
AST/ALT | 0.6 (0.2) | 0.6 (0.2) | |
Glucose (mmol/L) | 6.8 (2.8) | 5.0 (0.4) | 0.02 |
Insulin (pmol/L) | 108.6 (55.0) | 38.6 (20.7) | < 0.001 |
HOMA-IR | 4.8 (3.7) | 1.2 (0.7) | < 0.001 |
Cholesterol (mmol/L) | 5.4 (0.9) | 5.1 (0.5) | |
LDL-C (mmol/L) | 3.4 (0.9) | 3.6 (0.4) | |
HDL-C (mmol/L) | 1.2 (0.3) | 1.2 (0.3) | |
Triglyceride (mmol/L) | 1.7 (0.7) | 0.8 (0.5) | < 0.001 |
Uric acid (μmol/L) | 317.4 (83.8) | 263.5 (53.9) | 0.01 |
Table 3 Univariate analysis for predictive factors of NASH
Factor | Odds ratio | 95% CI | P-value |
Hypertension | 6.50 | 1.82-23.21 | 0.004 |
Body mass index (kg/m2) | 1.38 | 1.14-1.67 | 0.001 |
Triceps skin fold (mm) | 1.11 | 1.01-1.21 | 0.024 |
Waist circumference (cm) | 1.18 | 1.09-1.29 | < 0.001 |
Fat mass (kg) | 1.28 | 1.11-1.47 | 0.001 |
Visceral fat area > 158 (cm2) | 19.33 | 2.31-161.55 | < 0.001 |
Subcutaneous fat area (cm2) | 1.01 | 1.01-1.02 | 0.001 |
Glucose (mmol/L) | 2.88 | 1.29-6.43 | 0.01 |
Insulin > 11.9 (pmol/L) | 58.00 | 6.87-489.58 | < 0.001 |
HOMA-IR > 2.8 | 38.50 | 7.41-199.87 | < 0.001 |
Triglyceride > 1.70 (mmol/L) | 19.33 | 2.31-161.55 | 0.006 |
Uric acid (μmol/L) | 1.97 | 1.12-3.47 | 0.019 |
Table 4 Correlation of visceral fat with anthropometric and metabolic parameters
Parameter | Correlation coefficient (r) | P-value |
Systolic blood pressure | 0.31 | 0.02 |
Diastolic blood pressure | 0.35 | 0.006 |
Body mass index | 0.66 | < 0.001 |
Abdominal fat | 0.74 | < 0.001 |
Glucose | 0.39 | 0.002 |
Insulin | 0.47 | < 0.001 |
HOMA-IR | 0.47 | < 0.001 |
Triglyceride | 0.38 | 0.003 |
Table 5 Univariate analysis for risk factors of advanced stage of NASH
Factor | Odds ratio | 95% CI | P-value |
Waist-to-hip ratio > 0.88 | 4.57 | 0.90-23.14 | |
AST/ALT ratio > 0.65 | 12.25 | 1.27-118.36 | 0.03 |
HOMA-IR > 3.5 | 7.56 | 1.50-38.15 | 0.014 |
Grading of portal inflammation | 4.3 | 1.31-14.08 | 0.016 |
Grading of NASH | 4.0 | 1.18-13.51 | 0.026 |
Grading of steatosis | 1.02 | 0.38-2.73 |
- Citation: Sobhonslidsuk A, Jongjirasiri S, Thakkinstian A, Wisedopas N, Bunnag P, Puavilai G. Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis. World J Gastroenterol 2007; 13(26): 3614-3618
- URL: https://www.wjgnet.com/1007-9327/full/v13/i26/3614.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i26.3614