Piepoli A, Gentile A, Valvano MR, Barana D, Oliani C, Cotugno R, Quitadamo M, Andriulli A, Perri F. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. World J Gastroenterol 2006; 12(39): 6343-6348 [PMID: 17072959 DOI: 10.3748/wjg.v12.i39.6343]
Corresponding Author of This Article
Dr Ada Piepoli, Research Laboratory Department of Gastroenterology, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, Italy. a.piepoli@operapadrepio.it
Article-Type of This Article
Rapid Communication
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Table 3 Allele and genotype frequencies of UGT1A7 and UGT1A9 gene polymorphisms in pancreatic cancers and controls n (%)
Polymorphisms
Cases (n = 61)
Controls(n = 105)
UGT1A7 (exon 1)
Allele frequencies
*1
54 (44.3)
74 (35.0)
*2
15 (12.3)
46 (22.0)
*3
52 (42.6)
89 (42.0)
*4
1 (0.8)
1 (1.0)
CLUMP (T1): χ2 = 5.66 (df = 3), P = 0.10
CLUMP (T3-column used 2): χ2 = 4.75 (df = 1), Pc = 0.07 (uncorrected P = 0.03)
Genotype frequencies
*1*1
10 (16.4)
14 (13.3)
*1*2
7 (11.5)
12 (11.4)
*2*2
2 (3.3)
6 (5.7)
*1*3
26 (42.6)
34 (32.4)
*2*3
4 (6.6)
22 (21.0)
*3*3
11 (18.0)
16 (15.2)
*1*4
1 (1.6)
0 (0.0)
*3*4
0 (0.0)
1 (1.0)
CLUMP (T1): χ2 = 9.43 (df = 9), P = 0.21
CLUMP (T3-column used 5): χ2 = 6.05 (df = 1), Pc = 0.07 (uncorrected P = 0.01)
UGT1A9 (exon 1)
Allele frequencies
*1
121 (99.2)
206 (98.0)
*5
1 (0.8)
2 (1.0)
*4
0 (0.0)
2 (1.0)
CLUMP (T1): χ2 = 1.19 (df = 2), P = 0.79
Genotype frequencies
*1*1
60 (98.4)
101 (96.2)
*1*5
1 (1.6)
2 (1.9)
*1*4
0 (0.0)
2 (1.9)
CLUMP (T1): χ2 = 1.19 (df = 5), P = 0.79
Table 4 Allele and genotype frequencies of ARP, SPINK1 and CFTR gene polymorphisms in pancreatic cancers and controls
Polymorphisms
Cases(n = 61)
Controls(n = 105)
ARP
Allele frequencies
*1
4 (3.3)
4 (2.0)
*2
4 (3.3)
7 (3.0)
*3
111 (91.0)
195 (93.0)
*4
1 (0.8)
0 (0.0)
*5
1 (0.8)
2 (1.0)
*6
1 (0.8)
0 (0.0)
*7
0 (0.0)
2 (1.0)
CLUMP (T1): χ2 = 5.25 (df = 6), P = 0.52
Genotype frequencies
*1*3
4 (6.6)
4 (3.8)
*2*3
4 (6.6)
7 (6.7)
*3*3
50 (82.0)
90 (85.7)
*3*4
1 (1.6)
0 (0.0)
*3*5
1 (1.6)
2 (1.9)
*3*6
1 (1.6)
0 (0.0)
*3*7
0 (0.0)
2 (1.9)
CLUMP (T1): χ2 = 5.29 (df = 27), P = 0.54
SPINK1 (exon 3)
Allele frequencies
wt
117 (95.9)
206 (98.0)
P55S
4 (3.3)
2 (1.0)
N34S
1 (0.8)
2 (1.0)
CLUMP (T1): χ2 = 2.36 (df = 2), P = 0.29
Genotype frequencies
wt/wt
56 (91.8)
101 (96.2)
wt/P55S
4 (6.6)
2 (1.9)
wt/N34S
1 (1.6)
2 (1.9)
CLUMP (T1): χ2 = 2.40 (df = 5), P = 0.30
CFTR
Allele frequencies
wt
119 (97.5)
206 (98.0)
∆F508
3 (2.5)
4 (2.0)
CLUMP (T1): χ2 = 0.11 (df = 1), P = 1.0
Genotype frequencies
wt/wt
58 (95.1)
101 (96.2)
wt/∆F508
3 (4.9)
4 (3.8)
CLUMP (T1): χ2 = 0.11 (df = 2), P = 1.0
Citation: Piepoli A, Gentile A, Valvano MR, Barana D, Oliani C, Cotugno R, Quitadamo M, Andriulli A, Perri F. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. World J Gastroenterol 2006; 12(39): 6343-6348