Lu AP, Zhang SS, Zha QL, Ju DH, Wu H, Jia HW, Xiao C, Li S, Jian H. Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori infection and symptoms in patients with chronic gastritis. World J Gastroenterol 2005; 11(16): 2486-2490 [PMID: 15832423 DOI: 10.3748/wjg.v11.i16.2486]
Corresponding Author of This Article
Dr. Ai-Ping Lu, Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Dongzhimen, Beijing 100700, China. catcm@public.bta.net.cn
Article-Type of This Article
Brief Reports
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Table 2 Correlation between symptoms and CD4 cell infiltrations.
P
Symptom
P = 0.01-0.05
Heavy head or heavy body (t = 2.563), thirst (t = 2.478)
P = 0.06-0.2
Lower spirit, weakness of body or faint limbs, irritation
P = 0.21-0.5
Stomachache, hard stool, weak taste without thirst, distending fullness in chest, cool limbs with aversion to cold
P>0.6
Distending fullness in abdomen, diarrhea, constipation, acid regurgitation and epigastric upset, nausea or vomiting
Table 3 Correlation between symptoms and CD8 cell infiltrations.
P
Symptom
P = 0.01-0.05
Cool limbs with aversion to cold (t = 2.872)
P = 0.06-0.2
Stomachache, nausea or vomiting
P = 0.21-0.5
Weakness of body or faint limbs
P>0.6
Heavy feeling of head or body, thirst, distending fullness in abdomen, diarrhea, constipation, acid regurgitation and epigastric upset, hard stool, weak taste without thirst, distending fullness in chest, lower spirit, irritation
Table 4 Effect of symptom assemblages on the predicted percentage of CD4 and CD8 cell infiltrations.
Symptom
Cell level
Predicted percentage of CD4
Predicted percentage of CD8
Digestion related
Lower
62.5
89.2
Higher
62.1
16.7
Overall
62.3
60.7
Non-digestion related
Lower
75.0
83.8
Higher
58.6
50.0
Overall
67.2
70.5
Table 5 Effect of symptom assemblages on the predicted percentage of H pylori infection.
Symptom
H pylori infection
Predicted percentage
Digestion related
Negative
17.6
Positive
95.5
Overall
73.8
Non-digestion related
Negative
41.2
Positive
93.2
Overall
78.7
Table 6 Effect of symptom assemblage based on K-mean cluster analysis on the predicted percentage of CD4 and CD8 infiltrations and H pylori infection.
Table 7 Difference of symptoms between the two clusters of cases based on the symptoms, CD4 and CD8 cell infiltrations.
P
Symptom
P = 0.01-0.05
Weakness of body or faint limbs (F = 5.005), lower spirit (F = 5.750), hard stool (F = 5.835)
P = 0.06-0.2
Constipation, thirst, distending fullness in chest, nausea or vomiting
P = 0.21-0.5
Stomachache, diarrhea, weak taste without thirst, cool limbs with aversion to cold
P>0.6
Heavy feeling of head or body, distending fullness in abdomen, acid regurgitation and epigastric upset, irritation
Citation: Lu AP, Zhang SS, Zha QL, Ju DH, Wu H, Jia HW, Xiao C, Li S, Jian H. Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori infection and symptoms in patients with chronic gastritis. World J Gastroenterol 2005; 11(16): 2486-2490