Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

Table 1 Comparison of serum anti-H pylori IgG titers (mean ± SD) and grade of mucosal atrophy

	Anti-H pylori IgG, EIU
No antral or corpus atrophy	85.68 ± 17.81
No antral atrophy	62.29 ± 12.02
Mild antral atrophy	78.25 ± 5.86
Moderate antral atrophy	74.08 ± 4.39
Severe antral atrophy	73.38 ± 5.38
No corpus atrophy	68.76 ± 8.35
Mild corpus atrophy	77.21 ± 6.13
Moderate corpus atrophy	76.47 ± 5.04
Severe corpus atrophy	72.61 ± 4.72

Table 2 Comparison of serum PG1 and G17 levels (mean ± SD) and grade of IM

	No IM	Mild IM	Moderate IM	Severe IM
PG-1, µg/L	52.5 ± 7.74	66.07 ± 8.36	82.65 ± 10.72a	53.08 ± 12.24
G-17, pmol/L	6.79 ± 0.55	5.48 ± 0.50	4.73 ± 0.67a	5.11 ± 1.02

^aP < 0.05 vs non-metaplastic state.

Table 3 Comparison of serum PG1 and G17 levels (mean ± SD) and the grade of dysplasia

	No	Mild	Moderate	Severe
	dysplasia	dysplasia	dysplasia	dysplasia
PG-1, µg/L	33.6 ± 5.41	79.98 ± 7.92a	84.41 ± 10.98a	71.88 ± 27.25
G-17, pmol/L	7.37 ± 0.46	5.28 ± 0.50a	3.73 ± 0.66a	4.53 ± 1.95

^aP < 0.05 vs non-dysplastic state.

Table 4 Correlations between results of different methods in diagnosis of gastric mucosal changes

Parameters	rs
Detection of IM by endoscopy and histology	0.41
Detection of IM by chromoendoscopy and histology	0.92
Detection of antral atrophy by histology	-0.75
and serum levels of G-17
Detection of corpus atrophy by histology	-0.71
and serum levels of PG-1
Degree of stomach mucosal atrophy and IM	0.21
Degree of stomach mucosal atrophy and dysplasia	0.23
Degree of IM and dysplasia	0.41

Table 5 Sensitivity (Se) and specificity (Sp), PPV and NPV of Biohit GastroPanel^® in diagnosis of antral mucosal atrophy

Degree of antral atrophy	Se (%)	Sp (%)	PPV (%)	NPV (%)
(by histology)
No	83	95	53	99
Mild	61	84	45	91
Moderate	67	90	81	81
Severe	89	99	98	94

Table 6 Sensitivity (Se) and specificity (Sp), PPV and NPV of Biohit GastroPanel^® in diagnosis of corpus mucosal atrophy

Degree of corpus atrophy	Se (%)	Sp (%)	PPV (%)	NPV (%)
(by histology)
No	92	97	98	91
Mild	71	92	48	97
Moderate	72	96	81	93
Severe	88	97	82	98

Table 7 Sensitivity (Se) and specificity (Sp), PPV and NPV of routine endoscopy and chromoendoscopy in diagnosis of in-testinal metaplasia (IM)

	Routine endoscopy				Chromoendoscopy
	Se (%)	Sp (%)	PPV (%)	NPV (%)	Se (%)	Sp (%)	PPV (%)	NPV (%)
No	98	6	35	86	94	99	98	97
Mild	4	98	50	68	88	88	79	94
Moderate	no data	no data	no data	no data	71	95	80	92
Severe	6	99	33	89	82	98	82	98