Association of interleukin-12 p40 gene 3’-untranslated region polymorphism and outcome of HCV infection

Table 1 Features of subjects enrolled in the study

Group	n	Gender(male/female)	Age(yr)	Duration of infection (yr)
Self-limited infection	42	13/29	45.71 ± 7.68	17.76 ± 3.82
Persistent infection	91	48/43	46.85 ± 8.56	18.44 ± 3.82

Table 2 Genotype frequencies of 1188A/C SNP of IL12B in patients

Genotype	Self-limited infection (%)n = 42	Persistent infection (%)n = 91	OR	95%CI	P
AA	8 (19.0)	37 (40.7)	0.34	0.12-0.87	0.014
CC	7 (16.7)	23 (25.3)	0.59	0.20-1.61	0.270
AC	27 (64.3)	31 (34.1)	3.48	1.52-8.10	0.001

Comparisons of genotype distribution using chi square test showed significant difference between self-limited infection and persistent infection (P = 0.004).

Table 3 Multivariate analysis of the effects of variables on the outcome of HCV infection

Variable	P	Multivariate odds ratio (95%CI)
Genotype	0.001	0.43 (0.27-0.70)
Gender	0.029	0.41 (0.18-0.91)
Duration of infection	NS	-

Table 4 Characteristics of patients with different SNP (1188A/C) genotypes during persistent infection

Characteristics	AA n = 38	CC n = 23	AC n = 30
Age (yr)	46.9 ± 8.2	46.7 ± 9.7	46.8 ± 8.4
Gender (male/female)	21/17	12/11	15/15
Duration of	18.0 ± 3.8	18.8 ± 4.0	18.1 ± 3.8
disease (yr)
ALT (U/L)	51 ± 44	51 ± 60	44 ± 26
AST (U/L)	50 ± 30	51 ± 34	47 ± 20
γ -GT (U/L)	24 ± 26	35 ± 33	28 ± 34
ALP (U/L)	88 ± 26	92 ± 28	93 ± 22
Tbil (μmol/L)	29 ± 11	8.95 ± 2.59	10.1 ± 4.2
Dbil (μmol/L)	5.8 ± 2.0	5.3 ± 2.2	5.4 ± 2.4
Tp (g/L)	75.3 ± 3.9	72.24 ± 5.95	75.0 ± 5.8
ALB (g/L)	44.4 ± 2.3	43.8 ± 2.3	44.5 ± 2.6
A/G	1.46 ± 0.21	1.59 ± 0.32	1.51 ± 0.30
HCV RNA1	5.07 ± 1.49	4.95 ± 1.52	5.58 ± 1.24

¹Values are expressed as log₁₀ RNA copies per mL