Repeat ablation and single-session ablation in patients with multiple colorectal cancer liver metastases after chemotherapy failure

Figure 1 Flowchart of patients enrolled for multiple colorectal liver metastases ablation. CRLM: Colorectal liver metastases.

Figure 2 Single-session ablation: A 62-year-old male underwent successful ablation of two colorectal liver metastases in liver segments S4 and S6 during a single-session ablation procedure. A: Pre-ablation imaging (orange arrows point to the target lesion); B: Intraoperative contrast-enhanced ultrasound; C: Post-ablation imaging.

Figure 3 Repeat ablation: A 58-year-old male patient with an initial total of 9 colorectal liver metastases completed ablation in 3 sessions. Within 3 months, 2, 3, and 4 lesions were ablated separately. A: Pre-ablation imaging (orange arrows point to the target lesion); B: Intraoperative contrast-enhanced ultrasound/ultrasound; C: Post-ablation imaging.

Figure 4 Survival distribution at every phase.

Figure 5 Corresponding Kaplan-Meier curves for overall survival. A: Total Kaplan-Meier curves for overall survival (OS); B: Kaplan-Meier curves for OS with two ablation cohort; C-E: Kaplan-Meier curves for OS with age, lesion size and recurrence; F: The cumulative incidence curve.

Figure 6 Corresponding Kaplan-Meier curves for progression-free survival. A: Total Kaplan-Meier curves for progression-free survival (PFS); B: Kaplan-Meier curves for PFS with two ablation cohort; C-E: Kaplan-Meier curves for PFS with size, quantity and times; F: Kaplan-Meier curves for PFS with size in repeat ablation.