Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy

Figure 1 Remission and steroid-free remission rates in cytapheresis therapy in patients with ulcerative colitis concomitantly treated with thiopurines or immunomodulators. Box plot shows that, in cytapheresis therapy, the remission rates range from 40.3%-73% (mean: 56.25%, median: 55.85%, interquartile range: 41.475%-71.425%) and the rates of steroid-free remission range from 36%-56.3% (mean: 47.25%, median: 48.35%, interquartile range: 37.425%-55.975%).

Figure 2 Remission and steroid-free remission rates in cytapheresis therapy in patients with ulcerative colitis concomitantly treated with thiopurines or immunomodulators and in those treated without thiopurines or immunomodulators. A: Box plot shows that the rates of remission in patients concomitantly treated with thiopurines or immunomodulators (IM) and in those treated without thiopurines or IM range from 45%-73% (mean: 61.57%, median: 66.7%) and 48%-71% (mean: 62.7%, median: 69.1%), respectively; B: The rates of steroid-free remission in patients with ulcerative colitis (UC) concomitantly treated with thiopurines or IM are 41.7% and 56.3% (mean: 49%), and those in patients with UC treated without thiopurines or IM are 45.5% and 53.5% (mean: 49.5%), respectively.

Figure 3 Remission rates in cytapheresis therapy in patients with ulcerative colitis exposed to anti-tumor necrosis factor-α treatment and in those unexposed to anti-tumor necrosis factor-α treatment. The remission rates in patients with ulcerative colitis (UC) exposed to anti-tumor necrosis factor-α (TNF-α) treatment are 27.8% and 31% (mean: 29.4%), and those in patients with UC unexposed to anti-TNF-α treatment are 40.3% and 48% (mean: 44.15%), respectively.

Figure 4 Rates of remission or response and steroid-free remission in the combination therapies of cytapheresis and biologics in inflammatory bowel disease patients showing insufficient response or loss of response to biologics. Box plot shows that the remission rates in the combination therapies of cytapheresis and biologics range from 32%-100% (mean: 62.72%, median: 57.85%, interquartile range: 40.175%-89.275%), and the rates of steroid-free remission in the combination therapies range from 9%-75% (mean: 43%, median: 44%, interquartile range: 16.25%-68.75%).

Figure 5 Rates of remission or response and steroid-free remission in the combination therapies of cytapheresis and biologics in patients with ulcerative colitis showing insufficient response or loss of response to biologics. Box plot shows that the remission rates in the combination therapies of cytapheresis and biologics range from 32%-69% (mean: 47.97%, median: 42.9%), and the rates of steroid-free remission in the combination therapies range from 9%-75% (mean: 40.7%, median: 38%).