Retrospective Cohort Study
Copyright ©The Author(s) 2021.
World J Gastroenterol. Oct 28, 2021; 27(40): 6927-6938
Published online Oct 28, 2021. doi: 10.3748/wjg.v27.i40.6927
Figure 1
Open in New Tab Full Size Figure Download Figure
Figure 1 Patient flowchart. NUC: Nucleos(t)ide analog; Peg-IFN: Peginterferon.
Figure 2
Open in New Tab Full Size Figure Download Figure
Figure 2 Time-dependent distribution of serum quantitative hepatitis B core-related antigen in patients with chronic hepatitis B and treated with different regimens. A: Changes in hepatitis B core-related antigen (HBcrAg) levels during treatment in the entecavir group; B: Changes in HBcrAg levels during treatment in the peginterferon group; C: Changes in HBcrAg levels during treatment in all patients; D: Comparison of the decrease in HBcrAg levels from baseline to week 48 between the entecavir and peginterferon groups. cP < 0.0001. HBcrAg: Hepatitis B core-related antigen; IFN: Interferon.
Figure 3
Open in New Tab Full Size Figure Download Figure
Figure 3 Correlation of serum quantitative hepatitis B core-related antigen with covalently closed circular DNA, pregenomic RNA, serum, and intrahepatic hepatitis B virus DNA level. A: In all patients at baseline; B: In all patients at week 48; C: Entecavir at week 48; D: Peginterferon at week 48. cccDNA: Covalently closed circular DNA; ETV: Entecavir; HBV: Hepatitis B virus; IFN: Interferon. pgRNA: Pregenomic RNA.
Figure 4
Open in New Tab Full Size Figure Download Figure
Figure 4 Correlation of serum hepatitis B surface antigen with covalently closed circular DNA. A: Correlation between serum hepatitis B surface antigen (HBsAg) and intrahepatic covalently closed circular DNA (cccDNA) at baseline; B: Correlation between serum HBsAg and intrahepatic cccDNA and at week 48; C: Correlation between cccDNA and HBsAg levels at weeks 48 in the entecavir cohort; D: Correlation between cccDNA and HBsAg levels at weeks 48 in the interferon cohort. HBsAg: Hepatitis B surface antigen; cccDNA: Covalently closed circular DNA.
Figure 5
Open in New Tab Full Size Figure Download Figure
Figure 5 Hepatitis B core-related antigen prediction of hepatitis B e antigen seroconversion at 48 wk. A: Concentration of hepatitis B core-related antigen (HBcrAg) at different times in the two groups of hepatitis B e antigen (HBeAg) seroconversion; B: Receiver operating characteristic curve analysis of HBcrAg to predict HBeAg seroconversion. HBcrAg: Hepatitis B core-related antigen; HBeAg: Hepatitis B e antigen; ROC: Receiver operating characteristic; W: Week.