Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer

Figure 1 An example of the K-ras mutation analysis by CGCE method. A: sample without mutation; B: sample with K-ras mutation in codon 12.

Figure 2 An example of LOH at chromosome 9p, analysis by CGCE method. A: tumor sample with allelic loss; B: blood sample with both alleles present.

Figure 3 Four-step diagnostic algoritm evaluating FNA cytology and genetic changes for differentiation of benign and malignant lesions of the pancreas.