Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats

Figure 1 Pathology observation of the experimental rat liver sections stained with hematoxylin and eosin (×100). A: normal rats; B: control rats; C: CCl₄ treated rats at 3 wk; D: CCl₄ treated rats at 6 wk; E: CCl₄ treated rats at 9 wk; F: CCl₄ treated rats at 12 wk; G: CCl₄ treated rats at 15 wk; H: CCl₄ treated rats at 18 wk.

Figure 2 Pathology observation of the experimental rat liver sections stained with hematoxylin and eosin (×400). The arrow shows atypical hyperplasia in the epithelium of bile capillary. A, B, C, D, E, F, G, H, see Figure 1.

Figure 3 Expression of Smad2 mRNA in experimental rats liver sections during and after fibrosis (in situ hybridization ×400). A, B, C, D, E, F, G, H, see Figure 1.

Figure 4 Expression of Smad4 mRNA in experimental rats liver sections during and after fibrosis (in situ hybridization ×400). A, B, C, D, E, F, G, H, see Figure 1.