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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2026; 32(8): 116173
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.116173
Targeting Dialister-driven succinate accumulation: A novel strategy for Crohn’s disease activity control and recurrence prevention
Sheng Xu, Zheng Zhu, Hui-Ming Zhang, Yue-Ting Xu, Pei-Hong Shi, Yang Zheng, Yi-Tong Chen, Guang-Rong Lu, Bin-Jiao Zheng
Sheng Xu, Guang-Rong Lu, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Zheng Zhu, Hui-Ming Zhang, Yue-Ting Xu, Pei-Hong Shi, Yang Zheng, The Second School of Medicine, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Yi-Tong Chen, The First School of Medicine, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Bin-Jiao Zheng, Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Bin-Jiao Zheng, Department of Cell Biology and Genetics, School of Basic Medical Sciences, University of South China, Hengyang 421001, Hunan Province, China
Bin-Jiao Zheng, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
Co-corresponding authors: Guang-Rong Lu and Bin-Jiao Zheng.
Author contributions: Xu S contributed to manuscript writing and editing; Zhu Z and Zhang HM performed the literature search; Xu YT and Shi PH created the outline of the manuscript; Zheng Y and Chen YT supervised the study; Lu GR and Zheng BJ contributed to conceptualization and critical revisions, and contributed equally to this work as co-corresponding authors. All authors have read and approved the final manuscript.
Supported by Zhejiang Province Medical and Health Science and Technology Plan Project, No. 2024KY1239; Wenzhou Science and Technology Plan Project, No. Y2023107; and Talent Launch Project of Wenzhou Medical University, No. KYYW202434.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Bin-Jiao Zheng, PhD, Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, University Town, Chashan, Wenzhou 325000, Zhejiang Province, China. gusdy13x@wmu.edu.cn
Received: November 5, 2025
Revised: December 8, 2025
Accepted: December 24, 2025
Published online: February 28, 2026
Processing time: 99 Days and 6.4 Hours
Core Tip

Core Tip: Crohn’s disease (CD) greatly affects patients’ quality of life, necessitating new treatment strategies. Boronat-Toscano et al examined the role of Dialister and succinate in CD by analyzing the fecal microbiota, circulating succinate levels, and clinical indices. They found that high succinate levels are linked to active CD and inflammation, with Dialister enrichment related to impaired succinate clearance and recurrence. These findings highlight succinate and Dialister as therapeutic targets, enhancing understanding of CD and guiding future research. Larger studies should validate these results, explore Dialister’s metabolic mechanisms, and develop treatments targeting the “succinate axis” to link basic research to clinical practice.