©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2026; 32(8): 116016
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.116016
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.116016
Peroxiredoxin 1 as a novel pyroptosis inducer in colorectal cancer: Insights and future directions
Zi-Ke Chen, Jia-Wei Zhao, Wen-Ying Meng, Yu-Gang Wang, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Zi-Ke Chen, Jia-Wei Zhao, Yu-Gang Wang, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Zi-Ke Chen, Jia-Wei Zhao, Wen-Ying Meng, Yu-Gang Wang, Key Laboratory for Translational Research and Innovative Therapeutics of Gastrointestinal Oncology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Co-first authors: Zi-Ke Chen and Jia-Wei Zhao.
Co-corresponding authors: Wen-Ying Meng and Yu-Gang Wang.
Author contributions: Chen ZK and Zhao JW wrote the original draft and are co-first authors; Meng WY and Wang YG edited and reviewed the content and are co-corresponding authors; all authors approved the final version to publish.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Yu-Gang Wang, MD, Chief Physician, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, China. wang_yugang@sina.com
Received: October 31, 2025
Revised: December 6, 2025
Accepted: December 24, 2025
Published online: February 28, 2026
Processing time: 103 Days and 14.8 Hours
Revised: December 6, 2025
Accepted: December 24, 2025
Published online: February 28, 2026
Processing time: 103 Days and 14.8 Hours
Core Tip
Core Tip: Pyroptosis is a key link of “cell death-anti-tumor immunity” in colon cancer, which not only directly suppresses tumor through gasdermin D-mediated cell lysis, but also releases inflammatory factors to remodel the immune microenvironment. In the future, advancing targeted pyroptosis strategies toward molecular intervention, deepening mechanistic insights, and validating multi-dimensional approaches will be crucial to address current challenges and improve outcomes in colon cancer treatment.