Wan KR, Qian C, Liu LM. Bidirectional regulation between the endocrine system and liver: From mechanisms to multidisciplinary clinical care. World J Gastroenterol 2026; 32(6): 115232 [PMID: 41695282 DOI: 10.3748/wjg.v32.i6.115232]
Corresponding Author of This Article
Li-Mei Liu, PhD, Associate Professor, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, No. 131 Yubei Road, Shapingba District, Chongqing 400030, China. limeilliu@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 14, 2026 (publication date) through Feb 25, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Wan KR, Qian C, Liu LM. Bidirectional regulation between the endocrine system and liver: From mechanisms to multidisciplinary clinical care. World J Gastroenterol 2026; 32(6): 115232 [PMID: 41695282 DOI: 10.3748/wjg.v32.i6.115232]
World J Gastroenterol. Feb 14, 2026; 32(6): 115232 Published online Feb 14, 2026. doi: 10.3748/wjg.v32.i6.115232
Bidirectional regulation between the endocrine system and liver: From mechanisms to multidisciplinary clinical care
Kai-Rui Wan, Cheng Qian, Li-Mei Liu
Kai-Rui Wan, Cheng Qian, Li-Mei Liu, School of Medicine, Chongqing University, Chongqing 400030, China
Kai-Rui Wan, Cheng Qian, Li-Mei Liu, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China
Co-corresponding authors: Cheng Qian and Li-Mei Liu.
Author contributions: Wan KR conceived and designed the study, and drafted the original manuscript. Qian C and Liu LM are designated as co-corresponding authors, with equally significant, indispensable contributions pivotal to the work’s development and completion. Specifically, Qian C guided the study’s academic framework, led systematic literature retrieval and in-depth critical analysis of core studies, refined the manuscript’s logical structure, and revised the early draft to align with the journal’s academic standards. Liu LM verified the rationality of experimental data and methodologies, drafted and refined the mechanism discussion, addressed peer review comments, and coordinated the final manuscript to meet all submission requirements. All authors have read and approved the final version of the manuscript.
Supported by the National Natural Sciences Foundation of China, No. 82273071.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for the manuscript.
Corresponding author: Li-Mei Liu, PhD, Associate Professor, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, No. 131 Yubei Road, Shapingba District, Chongqing 400030, China. limeilliu@126.com
Received: October 14, 2025 Revised: November 17, 2025 Accepted: December 15, 2025 Published online: February 14, 2026 Processing time: 113 Days and 23.5 Hours
Core Tip
Core Tip: The endocrine system and liver form a dynamic bidirectional network via hormone synthesis/metabolism and signaling regulation. Hormones (e.g., thyroid hormones, insulin) maintain hepatic glucose/lipid homeostasis and bile acid metabolism; conversely, chronic liver diseases disrupt endocrine balance through impaired hormone clearance, hypothalamic-pituitary axis dysfunction, and systemic inflammation, forming a “liver disease-endocrine disorder” vicious cycle. Key research gaps include insufficient exploration of the gut microbiota-endocrine-liver axis, lack of special population data, and delayed integration of emerging therapies. Future efforts should focus on molecular mechanism refinement, special population studies, and multidisciplinary team practice to achieve precise management of endocrine-related liver diseases.
