Feng W, Ye QW, Wang QL, Chen SY, Ma Y, Meng FL. Predictors of one-year adverse outcomes after laparoscopic resection for hepatocellular carcinoma: Development and validation of an early-warning model. World J Gastroenterol 2026; 32(6): 113195 [DOI: 10.3748/wjg.v32.i6.113195]
Corresponding Author of This Article
Wei Feng, Chief Physician, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Suqian Hospital of Xuzhou Medical University, No. 138 Huanghe South Road, Suqian 223800, Jiangsu Province, China. fengweisuqian@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 14, 2026 (publication date) through Feb 5, 2026
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Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Feng W, Ye QW, Wang QL, Chen SY, Ma Y, Meng FL. Predictors of one-year adverse outcomes after laparoscopic resection for hepatocellular carcinoma: Development and validation of an early-warning model. World J Gastroenterol 2026; 32(6): 113195 [DOI: 10.3748/wjg.v32.i6.113195]
World J Gastroenterol. Feb 14, 2026; 32(6): 113195 Published online Feb 14, 2026. doi: 10.3748/wjg.v32.i6.113195
Predictors of one-year adverse outcomes after laparoscopic resection for hepatocellular carcinoma: Development and validation of an early-warning model
Wei Feng, Qing-Wang Ye, Qi-Le Wang, Si-Ying Chen, Yao Ma, Fan-Lai Meng
Wei Feng, Qing-Wang Ye, Qi-Le Wang, Si-Ying Chen, Yao Ma, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian 223800, Jiangsu Province, China
Wei Feng, Qing-Wang Ye, Qi-Le Wang, Si-Ying Chen, Yao Ma, Department of Hepatobiliary and Pancreatic Surgery, Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian 223800, Jiangsu Province, China
Fan-Lai Meng, Department of Pathology, Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian 223800, Jiangsu Province, China
Co-first authors: Wei Feng and Qing-Wang Ye.
Author contributions: Feng W and Ye QW designed the study, collected and analyzed data, wrote the manuscript, and provided guidance, contributed equally as co-first authors; Feng W, Ye QW, Wang QL, Chen SY, Ma Y, and Meng FL participated in the study’s conception and data collection. All authors read and approved the final version.
Supported by Suqian Science and Technology Program, No. S202317; Medical Research Program of Jiangsu Provincial Health Commission, No. Z2023017; and Suqian Talent Elite Program, No. SQCG202409.
Institutional review board statement: This study was approved by the Ethic Committee of Nanjing Drum Tower Hospital Group Suqian Hospital, No. 2023035.
Informed consent statement: All research participants or their legal guardians provided informed written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Feng, Chief Physician, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Suqian Hospital of Xuzhou Medical University, No. 138 Huanghe South Road, Suqian 223800, Jiangsu Province, China. fengweisuqian@163.com
Received: September 12, 2025 Revised: November 7, 2025 Accepted: December 22, 2025 Published online: February 14, 2026 Processing time: 142 Days and 23.8 Hours
Core Tip
Core Tip: Preoperatively assess white blood cell count, alpha-fetoprotein, and liver function; evaluate tumor size and vascular or portal vein invasion through imaging; document cirrhosis status. Apply the least absolute shrinkage and selection operator-based model to calculate individualized 1-year risk and guide tailored postoperative follow-up. High-risk patients should undergo multidisciplinary team review and early intervention. Combine risk score output with albumin-bilirubin scoring to assess hepatic reserve, continuously refining thresholds to enhance accuracy, generalizability, and clinical utility. This integrative approach enables early identification of recurrence risk and supports precision management after minimally invasive resection for hepatocellular carcinoma.
