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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2026; 32(6): 113010
Published online Feb 14, 2026. doi: 10.3748/wjg.v32.i6.113010
Published online Feb 14, 2026. doi: 10.3748/wjg.v32.i6.113010
Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages
Peng-Chun Yang, Jing Wang, Cai-Hua Yan, Qi-Yi Li, Shi-Yu Li, Jian Li, Li-Jing Zhang, Chi-Bing Dai, Department of Gastroenterology, Affiliated Renhe Hospital of China Three Gorges University, Yichang 443001, Hubei Province, China
Chun-Yan Xiao, Department of Oncology, Yilin People’s Hospital of Yichang City, Yichang 443099, Hubei Province, China
Co-first authors: Peng-Chun Yang and Chun-Yan Xiao.
Author contributions: Yang PC and Xiao CY performed most of the experiment and data analysis, wrote the manuscript, and contributed equally as co-first authors; Li QY, Wang J, and Yan CH provided experiment assistance; Li SY, Li J, and Zhang LJ contributed to interpretation of the data and analyses; Dai CB provided experimental design and guidance. All of the authors have read and approved the manuscript.
Supported by Scientific Research Project of Hubei Provincial Health Commission, No. WJ2021F060; and the Open Fund of the Basic and Clinical Pathology Research Center of Three Gorges University, No. RHKFBL2022-13.
Institutional animal care and use committee statement: This study was approved by the Institutional Animal Care and Use Committee of China Three Gorges University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets generated and analyzed during the present study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chi-Bing Dai, Professor, Department of Gastroenterology, Affiliated Renhe Hospital of China Three Gorges University, No. 435 Yiling Road, Yichang 443001, Hubei Province, China. dchibing@126.com
Received: August 13, 2025
Revised: October 23, 2025
Accepted: December 11, 2025
Published online: February 14, 2026
Processing time: 173 Days and 23.7 Hours
Revised: October 23, 2025
Accepted: December 11, 2025
Published online: February 14, 2026
Processing time: 173 Days and 23.7 Hours
Core Tip
Core Tip: A high-fat diet increases fecal deoxycholic acid (DCA), inducing M1 macrophage polarization and intestinal inflammation. Bifidobacterium mitigates this by reducing the production of DCA, inhibiting M1 polarization, and partially restoring gut microbiota balance. Hence, they can be employed for treating high-fat diet-associated colitis. This study aims to investigate changes in intestinal flora, fecal DCA levels, and cytokine profiles.