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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2026; 32(5): 115673
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.115673
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.115673
Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment
Tayane C Morais, Genalva Couto, Raísa A Lisbôa, Genoile Oliveira Santana, Department of Life Sciences, Postgraduate Program in Pharmaceutical Sciences, Bahia State University, Salvador 41150-000, Bahia, Brazil
Bruno César da Silva, Division of Gastroenterology, Hospital da Bahia, Salvador 41810-011, Bahia, Brazil
Bruno César da Silva, Zane Cohen Centre for Digestive Diseases Lunenfeld-Tanenbaum Res
Bruna S da Cruz, Maria G F Viana, Gabriela B C de Sousa, Lara P Arenas, Erick S Nery, Dep
Flora Maria Lorenzo Fortes, Neogélia Pereira de Almeida, Andréa Maia Pimentel, Jaciane Araújo Mota Fontes, Valdiana Cristina Surlo, Outpatient Inflammatory Bowel Disease Unit, Hospital Geral Roberto Santos, Salvador 41180-000, Bahia, Brazil
Julio Fonseca Chebli, Inflammatory Bowel Diseases Center, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Minas Gerais, Brazil
Raquel Rocha, School of Nutrition, Federal University of Bahia, Salvador 40170-110, Bahia, Brazil
Co-corresponding authors: Raquel Rocha and Genoile Oliveira Santana.
Author contributions: Morais TC, da Silva BC, Arenas LP, Nery ES, and Santana GO contributed to writing the manuscript; Couto G, Lisbôa RA, Cruz BS, Viana MGF, and de Sousa GBC contributed to data collection and analysis; da Silva BC contributed to data organization and performed the statistical analysis; da Silva BC, Arenas LP, Nery ES, and Santana GO participated in critical revision of the final version; Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, and Surlo VC provided clinical advice for the study; Chebli JMF and Rocha R contributed to analysis and correction of the article; Santana GO supervised the study; Rocha R and Santana GO contributed equally to this manuscript and are co-corresponding authors.
Institutional review board statement: This study was conducted in accordance with Resolution No. 466/2012 of the National Health Council, which regulates research involving human beings in Brazil. This study was approved by the Ethics and Research Committee of Hospital Geral Roberto Santos (Approval No. 61349222.0.0000.5028).
Informed consent statement: All participants were informed about the objectives, procedures, risks, and benefits associated with the study and signed the Informed Consent Form before their inclusion. The consent process respected the principles of autonomy, confidentiality, beneficence, and non-maleficence, as established by Resolution No. 466/2012 of the National Health Council.
Conflict-of-interest statement: Chebli JF declares himself to be a speaker for Abbivie, Abbott, Johnson & Johnson and Takeda laboratories. Santana GO: Speaker- Abbvie, Johnson & Johnson, Ferring, Takeda; research - Abivax, Takeda, Johnson & Johnson, Roche, Sanofi, Polpharma; advisory board - Abbvie, Johnson & Johnson, MSD. There are no conflicts of interest to report by other authors.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement:
No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raquel Rocha, School of Nutrition, Federal University of Bahia, Rua Augusto Viana, Campus Universitário Canela, Salvador 40170-110, Bahia, Brazil.
Received: October 27, 2025
Revised: November 27, 2025
Accepted: December 23, 2025
Published online: February 7, 2026
Processing time: 93 Days and 12.2 Hours
Revised: November 27, 2025
Accepted: December 23, 2025
Published online: February 7, 2026
Processing time: 93 Days and 12.2 Hours
Core Tip
Core Tip: Fatigue is one of the most common and challenging symptoms reported by adults with inflammatory bowel disease. We evaluated the association between fatigue and sociodemographic profile, depression, anxiety, stress, insomnia, iron deficiency, vitamin B1 and B12 deficiencies, thyroid function, anemia, leukocyte count, and sedentary lifestyle in patients with Crohn’s disease (CD). An association was found with the following variables: Sedentary lifestyle, shorter time since CD diagnosis, combination of depression, anxiety, stress and insomnia, total leukocyte and segmented neutrophil levels, and reduced lymphocyte-eosinophil-lymphocyte ratio. These data may contribute to improving decision-making in the management of fatigue in patients with CD.