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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2026; 32(5): 114752
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114752
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114752
Correlation between sarcopenia and esophageal stenosis following endoscopic submucosal dissection and construction of a postoperative stenosis risk model
Kai-Zhe Yang, Li Xu, Qin Lu, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Lu Chen, Ming-Yue Li, Zhi Wang, Qin Lu, Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing 210009, Jiangsu Province, China
Bin-Xiang Xu, Department of Gastroenterology, Baoying County Hospital of Traditional Chinese Medicine, Yangzhou 225800, Jiangsu Province, China
Author contributions: Yang KZ contributed to data curation; methodology; writing - original draft; Xu L contributed to software; Xu BX and Wang Z contributed to validation; Lu Q contributed to conceptualization; Yang KZ, Chen L, Xu L and Li MY contributed to formal analysis; Yang KZ and Lu Q contributed to writing - review & editing; Li MY and Lu Q contributed to funding acquisition; and all contributing authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82300638; the General Program of Jiangsu Provincial Administration of Traditional Chinese Medicine, No. MS2024139; and Zhongda Hospital Affiliated to Southeast University, Jiangsu Province High-Level Hospital Construction Funds, No. YKK24268.
Institutional review board statement: This study was approved by the Ethics Committee of Southeast University, Zhongda Hospital Southeast University (approval No. 2025ZDSYLL373-P01). All study procedures adhered to the Declaration of Helsinki.
Informed consent statement: The ethics committee waived the requirement for obtaining informed consent from the patients owing to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to the manuscript.
Data sharing statement: The data used and analyzed during the study are available from the lead author and the corresponding authors upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qin Lu, MD, Associate Chief Physician, Research Fellow, Department of Gastroenterology, Zhongda Hospital Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. luqin81287@163.com
Received: September 28, 2025
Revised: November 20, 2025
Accepted: December 29, 2025
Published online: February 7, 2026
Processing time: 123 Days and 16.3 Hours
Revised: November 20, 2025
Accepted: December 29, 2025
Published online: February 7, 2026
Processing time: 123 Days and 16.3 Hours
Core Tip
Core Tip: A novel finding of this study is that a body composition abnormality, quantified by an index associated with computed tomography-defined sarcopenia, is a clinically significant and independent predictor of the development of esophageal stenosis after endoscopic submucosal dissection (ESD). We successfully constructed a risk prediction model for post-ESD stenosis that includes sarcopenia, which achieved good internal validation. This investigation addresses a li