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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2026; 32(5): 114497
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114497
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114497
Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer
Sevgi Kalkanli Tas, Duygu Kirkik, Department of Immunology, Faculty of Hamidiye Medicine, University of Health Sciences, Istanbul 34668, Türkiye
Furkan Aydın, Department of Immunology, Faculty of Medicine, Yeditepe University, Istanbul 34755, Ataşehir, Türkiye
Author contributions: Kalkanli Tas S designed the overall concept and outline of the manuscript; Kalkanli Tas S and Aydın F contributed to the discussion and design of the manuscript; Kalkanli Tas S, Aydın F, and Kirkik D contributed to the writing and editing of the manuscript, and literature review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sevgi Kalkanli Tas, Professor, Department of Immunology, Faculty of Hamidiye Medicine, University of Health Sciences, No. 38 Tıbbiye Cadde, Mekteb-i Tıbbiye-i Şâhane, Külliyesi Selimiye Mahalle, Istanbul 34668, Türkiye. skalkanlitas@gmail.com
Received: September 22, 2025
Revised: November 24, 2025
Accepted: December 15, 2025
Published online: February 7, 2026
Processing time: 129 Days and 18.5 Hours
Revised: November 24, 2025
Accepted: December 15, 2025
Published online: February 7, 2026
Processing time: 129 Days and 18.5 Hours
Core Tip
Core Tip: Gastric ulcer is a prevalent gastrointestinal disorder with multifactorial causes including Helicobacter pylori infection, non-steroidal anti-inflammatory drugs use, and systemic inflammation. Recent evidence highlights the role of complete blood count-derived inflammatory biomarkers - such as neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and particularly the systemic inflammatory response index - as promising noninvasive indicators for risk stratification. These inexpensive and accessible markers may provide valuable insights into immune dysregulation, predict disease severity, and guide individualized management, representing an important step toward precision gastroenterology.