Kalkanli Tas S, Aydın F, Kirkik D. Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer. World J Gastroenterol 2026; 32(5): 114497 [DOI: 10.3748/wjg.v32.i5.114497]
Corresponding Author of This Article
Sevgi Kalkanli Tas, Professor, Department of Immunology, Faculty of Hamidiye Medicine, University of Health Sciences, No. 38 Tıbbiye Cadde, Mekteb-i Tıbbiye-i Şâhane, Külliyesi Selimiye Mahalle, Istanbul 34668, Türkiye. skalkanlitas@gmail.com
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Gastroenterology & Hepatology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 7, 2026 (publication date) through Jan 28, 2026
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World Journal of Gastroenterology
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1007-9327
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Kalkanli Tas S, Aydın F, Kirkik D. Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer. World J Gastroenterol 2026; 32(5): 114497 [DOI: 10.3748/wjg.v32.i5.114497]
World J Gastroenterol. Feb 7, 2026; 32(5): 114497 Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114497
Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer
Sevgi Kalkanli Tas, Furkan Aydın, Duygu Kirkik
Sevgi Kalkanli Tas, Duygu Kirkik, Department of Immunology, Faculty of Hamidiye Medicine, University of Health Sciences, Istanbul 34668, Türkiye
Furkan Aydın, Department of Immunology, Faculty of Medicine, Yeditepe University, Istanbul 34755, Ataşehir, Türkiye
Author contributions: Kalkanli Tas S designed the overall concept and outline of the manuscript; Kalkanli Tas S and Aydın F contributed to the discussion and design of the manuscript; Kalkanli Tas S, Aydın F, and Kirkik D contributed to the writing and editing of the manuscript, and literature review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sevgi Kalkanli Tas, Professor, Department of Immunology, Faculty of Hamidiye Medicine, University of Health Sciences, No. 38 Tıbbiye Cadde, Mekteb-i Tıbbiye-i Şâhane, Külliyesi Selimiye Mahalle, Istanbul 34668, Türkiye. skalkanlitas@gmail.com
Received: September 22, 2025 Revised: November 24, 2025 Accepted: December 15, 2025 Published online: February 7, 2026 Processing time: 129 Days and 18.5 Hours
Abstract
Gastric ulcer (GU) remains a significant global health concern, often leading to severe complications such as bleeding and perforation. While Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use are well-recognized etiological factors, systemic inflammation plays a pivotal but underexplored role in GU pathogenesis. Shen et al provide compelling evidence linking complete blood count-derived inflammatory biomarkers with GU prevalence, identifying the systemic inflammatory response index as the most discriminative marker. Their cross-sectional analysis underscores the potential of routine hematological parameters as cost-effective, accessible tools for early identification of high-risk individuals. Importantly, this study adds to the growing body of literature suggesting that simple indices - neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and systemic inflammatory response index - may serve not only as diagnostic aids but also as windows into disease mechanisms involving immune dysregulation and oxidative stress. Future prospective and mechanistic studies are warranted to determine whether these markers can predict ulcer recurrence, guide therapeutic interventions, or integrate into precision gastroenterology. By leveraging widely available blood tests, we may move closer to a paradigm where inexpensive inflammatory indices refine GU risk stratification and management strategies.
Core Tip: Gastric ulcer is a prevalent gastrointestinal disorder with multifactorial causes including Helicobacter pylori infection, non-steroidal anti-inflammatory drugs use, and systemic inflammation. Recent evidence highlights the role of complete blood count-derived inflammatory biomarkers - such as neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and particularly the systemic inflammatory response index - as promising noninvasive indicators for risk stratification. These inexpensive and accessible markers may provide valuable insights into immune dysregulation, predict disease severity, and guide individualized management, representing an important step toward precision gastroenterology.
