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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2026; 32(5): 114245
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114245
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.114245
Defining endoscopic candidacy for intermediate size rectal neuroendocrine tumors
Yu-Hang Sheng, Qi-Yang Chen, Xiao-Meng Li, Zhi-Xiang Zhou, Tian-Le Xue, School of Biomedical Science and Technology, Yaoda Education Technology Development (Nanjing) Co., Ltd, No. 180 Ruanzhu Avenue, Yuhuatai District, Nanjing 210012, Jiangsu Province, China
Co-first authors: Yu-Hang Sheng and Qi-Yang Chen.
Author contributions: Sheng YH and Chen QY conducted the literature review, assisted with manuscript writing and formatting, data interpretation and preparation as co-first authors; Li XM reviewed the clinical and endoscopic aspects and provided methodological suggestions; Zhou ZX provided critical revisions for intellectual content; Xue TL conceived the idea and drafted and critically revised the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-Le Xue, PhD, School of Biomedical Science and Technology, Yaoda Education Technology Development (Nanjing) Co., Ltd, No. 180 Ruanzhu Avenue, Yuhuatai District, Nanjing 210012, Jiangsu Province, China. tianlexue114514@gmail.com
Received: September 15, 2025
Revised: October 31, 2025
Accepted: December 3, 2025
Published online: February 7, 2026
Processing time: 136 Days and 1.7 Hours
Revised: October 31, 2025
Accepted: December 3, 2025
Published online: February 7, 2026
Processing time: 136 Days and 1.7 Hours
Core Tip
Core Tip: A matched analysis from a high-volume center suggests that well differentiated rectal neuroendocrine tumors measuring 1.0-1.5 cm can be managed safely with endoscopic resection when selection and technique are optimized. The absence of lymphovascular invasion and the lack of observed recurrences in the intermediate group argue for an organ preserving pathway with structured staging and follow up.