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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2026; 32(4): 114897
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.114897
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.114897
Latent tuberculosis screening for inflammatory bowel disease in tuberculosis endemic region remains porous and suboptimal: A multicentre study
Daya Krishna Jha, Sonal Singh, Ajay Shankar Prasad, Rajat Shukla, Vivek Hande, Sandeep Thareja, Department of Gastroenterology, Army Hospital (Research and Referral), Delhi 110001, India
Shilpa Prasad, Arun Valsan, Priya Nair, Anoop K Koshy, Department of Gastroenterology, Amrita Institute of Medical Sciences, Kochi 682001, Kerala, India
Shubhra Mishra, Department of Gastroenterology, The Gastro Liver Hospital, Kanpur 208002, Uttar Pradesh, India
Rizwan Ahamed, Philip Augustine, Department Gastroenterology and Advanced Gastrointestinal Endoscopy, Center of Excellence in Gastrointestinal Sciences, Rajagiri Hospital, Aluva 683112, Kerala, India
Kartik Natarajan, Department of Gastroenterology, Apollo Hospitals, Chennai 600001, Tamil Nādu, India
Kiran Peddi, Department of Gastroenterology, Yashoda Hospital, Hyderabad 500001, Telangāna, India
Akshay Kulkarni, Department of Gastroenterology, Deenanath Mangeshkar Hospital, Pune 411004, Mahārāshtra, India
Sumit Bhatia, Department of Gastroenterology, Paras Hospital, Gurgaon 122001, Haryāna, India
Aditya V Pachisia, Department of Gastroenterology, Command Hospital, Bangalore 560007, Karnātaka, India
Pradeep K Singh, Department of Gastroenterology, Military Hospital Jalandhar, Jalandhar 144001, Punjab, India
Anuraag Jena, Department of Gastroenterology, Institute of Medical Sciences and SUM Hospital, Bhubaneshwar 751029, Odisha, India
Swatantra Gupta, Department of Gastroenterology, Dr. Rajendra Prasad Govt Medical College, Kangra 176001, India
Shubham Jain, Department of Gastroenterology, BYL Nair Hospital and Topiwala National Medical College, Mumbai 400008, Maharashtra, India
Kodavoor Padmaprakash, Department of Gastroenterology, Base Hospital, Delhi Cantonment 110001, Delhi, India
Rinkalben Kakadiya, Department of Gastroenterology, Surat Institute of Digestive Science, Surat 394230, India
Amit Kumar, Department of Gastroenterology, Indian Naval Hospital Ship Asvini, Mumbai 400001, Mahārāshtra, India
Siddharth Shukla, Department of Gastroenterology, Base Hospital, Guwahati 781001, Assam, India
Usha Dutta, Vishal Sharma, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Author contributions: Jha DK, Mishra S, Jena A, and Sharma V designed the study and performed the data analysis; Jha DK, Prasad S, Valsan A, Mishra S, Nair P, Koshy AK, Singh S, Prasad AS, Shukla R, Ahamed R, Augustine P, Natarajan K, Peddi K, Kulkarni A, Bhatia S, Pachisia AV, Singh PK, Jena A, Gupta S, Jain S, Padmaprakash K, Kakadiya R, Kumar A, Shukla S, Dutta U, Hande V, Thareja S, and Sharma V were involved in data collection and manuscript editing; Jha DK and Sharma V wrote the initial draft.
Institutional review board statement: The study was reviewed and approved by the Postgraduate Institute of Medical Education and Research Institutional Review Board, Reference No. IEC-INT/2023/Study-880.
Informed consent statement: The informed consent was waived because of the retrospective design of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Anonymized data may be obtained from first or corresponding author on a reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vishal Sharma, DM, Additional Professor, Department of Gastroen
Received: October 10, 2025
Revised: November 9, 2025
Accepted: December 11, 2025
Published online: January 28, 2026
Processing time: 113 Days and 23.6 Hours
Revised: November 9, 2025
Accepted: December 11, 2025
Published online: January 28, 2026
Processing time: 113 Days and 23.6 Hours
Core Tip
Core Tip: This multicenter study about inflammatory bowel disease patients on advanced therapy suggests that compliance with standard latent tuberculosis (LTB) screening, as recommended by LTB guidelines, is low at around 60%. Annual screening for LTB was found to be grossly neglected at 27%. Incidence of LTB was 10.7% and active tuberculosis (TB) developed in 4.5% of the patients on advanced therapy. Other interesting finding was occurrence of active TB with any advanced therapy, suggesting that there is no ‘safe’ therapy in TB endemic regions.