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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2026; 32(4): 113319
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.113319
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.113319
Clinical implications of a dynamic nomogram for predicting sepsis in acute liver failure
Shi-Yan Zhang, Department of Clinical Laboratory, Fuding Hospital, Fujian University of Traditional Chinese Medicine, Ningde 355200, Fujian Province, China
Jin-Bao Shi, Department of Nephrology, Fuding Hospital, Fujian University of Traditional Chinese Medicine, Ningde 355200, Fujian Province, China
Jin-Bao Shi, Department of Nephrology, Ningde Hospital of Traditional Chinese Medicine, Ningde 352100, Fujian Province, China
Author contributions: Zhang SY and Shi JB designed the overall concept and outline of the manuscript, reviewed the literature, and wrote and edited the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Bao Shi, MD, Professor, Department of Nephrology, Ningde Hospital of Traditional Chinese Medicine, No. 16 Donghu Road, Ningde 355200, Fujian Province, China. 1301803387@qq.com
Received: August 22, 2025
Revised: November 14, 2025
Accepted: December 22, 2025
Published online: January 28, 2026
Processing time: 153 Days and 22.6 Hours
Revised: November 14, 2025
Accepted: December 22, 2025
Published online: January 28, 2026
Processing time: 153 Days and 22.6 Hours
Core Tip
Core Tip: This letter highlights the development and validation of a dynamic nomogram for predicting sepsis risk in patients with acute liver failure. The sepsis in acute liver failure model shows robust discrimination, consistently outperforming the sequential organ failure assessment and systemic inflammatory response syndrome scores, and has been validated across both Western and Chinese intensive care unit cohorts. Future work should incorporate longitudinal clinical variables, integrate infection-related biomarkers, and pursue multicenter validation to further enhance clinical utility.