Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 14, 2026; 32(26): 119574
Published online Jul 14, 2026. doi: 10.3748/wjg.v32.i26.119574
Published online Jul 14, 2026. doi: 10.3748/wjg.v32.i26.119574
High cyclin-dependent kinase 5 expression promotes tumor progression in gastric neuroendocrine carcinoma
Yu-Qin Sun, Qiu-Xian Chen, Chen-Bin Lv, Ming-Qiao Lian, Wei-Ming Zeng, Yong-Bin Zhang, Li-Sheng Cai, Department of Gastrointestinal Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China
Jie Su, Department of Ultrasonography, Zhangpu Hospital, Zhangzhou 363000, Fujian Province, China
Kai-Ning Ye, En-Zhou Kang, Department of Pathology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China
Co-first authors: Yu-Qin Sun and Jie Su.
Author contributions: Sun YQ and Su J made equal contributions as co-first authors; Sun YQ, Su J, and Cai LS contributed to concept and design, drafting of the manuscript, and supervision; Ye KN, Chen QX, Kang EZ, Lv CB, Lian MQ, Zeng WM, and Zhang YB contributed to acquisition, analysis, or interpretation of data; Sun YQ, Su J, Zhang YB, and Zeng WM contributed to statistical analysis; Sun YQ, Su J, Ye KN, and Cai LS contributed to administrative, technical, or material support. All authors approved the final version to publish.
AI contribution statement: This article was translated using DeepL.
Supported by Natural Science Foundation of Fujian Province, No. 2025J011630; and the Climbing Fund of PhD Workstation, Zhangzhou Affiliated Hospital of Fujian Medical University, No. PDA202101.
Institutional review board statement: The study was approved by the Ethics Committee of the Zhangzhou Affiliated Hospital of Fujian Medical University, No.2026 LWB036.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Li-Sheng Cai, Department of Gastrointestinal Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, No. 59 West Shengli Road, Zhangzhou 363000, Fujian Province, China. wxccls2024@163.com
Received: February 2, 2026
Revised: February 23, 2026
Accepted: March 23, 2026
Published online: July 14, 2026
Processing time: 146 Days and 11.9 Hours
Revised: February 23, 2026
Accepted: March 23, 2026
Published online: July 14, 2026
Processing time: 146 Days and 11.9 Hours
Core Tip
Core Tip: This study aims to investigate the expression and function of cyclin-dependent kinase 5 (CDK5) in gastric neuroendocrine carcinoma (GNEC). The findings indicate that patients with elevated CDK5 expression in GNEC have a poor prognosis. Furthermore, CDK5 is identified as an independent prognostic risk factor and may play a critical role in the proliferation of GNEC.