He WT, Chen H, Li H, Li YL, Wu HR, Duan WB, Liu Y. Application of intraoperative laparoscopic ultrasound guidance combined with Sonazoid contrast in surgical treatment of colorectal liver metastasis. World J Gastroenterol 2026; 32(23): 117597 [DOI: 10.3748/wjg.v32.i23.117597]
Corresponding Author of This Article
Yang Liu, MD, Department of General Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 388 Renming Road, Changde 415000, Hunan Province, China. 15873639390@163.com
Research Domain of This Article
Gastroenterology & Hepatology
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research-article
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He WT, Chen H, Li H, Li YL, Wu HR, Duan WB, Liu Y. Application of intraoperative laparoscopic ultrasound guidance combined with Sonazoid contrast in surgical treatment of colorectal liver metastasis. World J Gastroenterol 2026; 32(23): 117597 [DOI: 10.3748/wjg.v32.i23.117597]
World J Gastroenterol. Jun 21, 2026; 32(23): 117597 Published online Jun 21, 2026. doi: 10.3748/wjg.v32.i23.117597
Application of intraoperative laparoscopic ultrasound guidance combined with Sonazoid contrast in surgical treatment of colorectal liver metastasis
Wen-Tao He, Hua Chen, Hong Li, Yu-Lin Li, Hao-Ran Wu, Wen-Bin Duan, Yang Liu
Wen-Tao He, Hua Chen, Hong Li, Yu-Lin Li, Hao-Ran Wu, Yang Liu, Department of General Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415000, Hunan Province, China
Wen-Bin Duan, Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, Changsha 410000, Hunan Province, China
Author contributions: He WT designed the research and wrote the first manuscript; He WT, Chen H, Li H, Wu HR, Duan WB, and Li YL contributed to conceiving the research and analyzing data; Liu Y conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Supported by Major Scientific Research Project of National Clinical Key Specialty, No. Z2023165.
Institutional review board statement: This study was approved by the Ethic Committee of The First People’s Hospital of Changde City (Approval No. 2024-104-02).
Informed consent statement: As the study used anonymous and pre-existing data, the requirement for the informed consent from patients was waived.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Corresponding author: Yang Liu, MD, Department of General Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 388 Renming Road, Changde 415000, Hunan Province, China. 15873639390@163.com
Received: January 30, 2026 Revised: March 1, 2026 Accepted: March 17, 2026 Published online: June 21, 2026 Processing time: 128 Days and 20.7 Hours
Core Tip
Core Tip: Advances in imaging technology have improved preoperative lesion localization and surgical planning by providing valuable visual references in the surgical treatment for liver metastases from colorectal cancer. However, strategies to better localize occult lesions intraoperatively following chemotherapy warrants further exploration. Sonazoid (Shizhuoan in Chinese) is a contrast agent taken up by Kupffer cells, which could facilitate further localization of hepatic lesions. However, reports on its intraoperative application in China remain limited. This study compared the visualization of target lesions during laparoscopic microwave ablation for colorectal liver metastases using Sonazoid-enhanced contrast-enhanced ultrasound vs gray-scale ultrasound.
