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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2026; 32(2): 114222
Published online Jan 14, 2026. doi: 10.3748/wjg.v32.i2.114222
Published online Jan 14, 2026. doi: 10.3748/wjg.v32.i2.114222
Reducing agents for induction and maintenance therapy achieve long-term remission of refractory ulcerative colitis: A case report and review of literature
Pamela B Sylvestre, Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45229, United States
Pamela B Sylvestre, Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, United States
Author contributions: Sylvestre PB confirms accountability for all aspects of this work and has approved it for publication; and responsibilities included drafting and critical revision of the manuscript, photography of pathology slides, and final approval of the version to be published.
Informed consent statement: Informed written consent has been obtained from the patient for publication of this report.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pamela B Sylvestre, MD, Professor, Pathology and Laboratory Medi
Received: September 16, 2025
Revised: November 13, 2025
Accepted: December 3, 2025
Published online: January 14, 2026
Processing time: 119 Days and 12.8 Hours
Revised: November 13, 2025
Accepted: December 3, 2025
Published online: January 14, 2026
Processing time: 119 Days and 12.8 Hours
Core Tip
Core Tip: Reducing agents, sodium thiosulfate and R-dihydrolipoic acid, are safe and highly effective to induce and maintain remission of ulcerative colitis, respectively, without the need for immunosuppressive drugs, even in patients who are refractory or poorly controlled by conventional and advanced therapies.