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LGALS1 drives chemoresistance in esophageal squamous cell carcinoma by modulating epithelial-mesenchymal transition and tumor immunity
Qi-Hang Yan, Chen-Di Xu, Zhen-Guo Li, Yu-Zhen Zheng, Wing-Shing Wong, Da-Chuan Liang, Jie Yang, Wu-Guang Chang, Jun-Ye Wang
Qi-Hang Yan, Chen-Di Xu, Zhen-Guo Li, Wing-Shing Wong, Da-Chuan Liang, Jie Yang, Jun-Ye Wang, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Qi-Hang Yan, Zhen-Guo Li, Yu-Zhen Zheng, Wing-Shing Wong, Jun-Ye Wang, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Yu-Zhen Zheng, Biomedical Innovation Center, Department of Thoracic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Wu-Guang Chang, Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China
Co-first authors: Qi-Hang Yan and Chen-Di Xu.
Co-corresponding authors: Wu-Guang Chang and Jun-Ye Wang.
Author contributions: Yan QH and Xu CD have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as co-first authors; Yan QH, Xu CD, and Li ZG conducted the study and wrote the manuscript; Zheng YZ, Wong WS, Liang DC, Yang J and Chang WG performed the bioinformatics analysis and data analysis; Chang WG and Wang JY design the research plan as co-corresponding authors; all authors reviewed and approved the manuscript.
Supported by National Natural Science Foundation of China, No. 82173293.
Institutional review board statement: This study was conducted ethically in accordance with the World Medical Association Declaration of Helsinki and approved by the Sun Yat-sen University Cancer Center Ethics Committee (No. SL-B2024-312-01).
Institutional animal care and use committee statement: The protocols for animal experiments were approved by the Institutional Animal Care and Use Committee of Sun Yat-sen University (No. L102012024070D), the tumor diameter of the mice in this study did not exceed 20 mm, which was in line with the laboratory animal management regulations of the National Institutes of Health of the United States.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Jun-Ye Wang, MD, Professor, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China.
wangjy@sysucc.org.cn
Received: November 18, 2025
Revised: December 18, 2025
Accepted: January 27, 2026
Published online: May 14, 2026
Processing time: 168 Days and 23.6 Hours
