Crosstalk between non-alcoholic fatty pancreas disease and metabolic dysfunction-associated steatotic liver disease: Immunometabolic interactions and clinical implications

Core Tip

Core Tip: Non-alcoholic fatty pancreas disease and metabolic dysfunction-associated steatotic liver disease are two distinct conditions caused by common metabolic disturbances, but with different pathogenesis. Despite their frequent co-occurrence, the degree of pancreatic steatosis may not directly correlate with the severity of liver fibrosis or inflammation, as demonstrated in recent studies. A key difference in their pathogenesis is linked to the structure and function of the cells in these organs. Understanding these differences is critical for developing organ-specific approaches to diagnosis and treatment.