Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; 32(13): 115440 [DOI: 10.3748/wjg.v32.i13.115440]
Corresponding Author of This Article
Qing-Qing Yu, Professor, Clinical Research Center, Jining No. 1 People's Hospital, No. 6 Jiankang Road, Jining 272000, Shandong Province, China. yuqingqing_lucky@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Apr 7, 2026 (publication date) through Mar 27, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; 32(13): 115440 [DOI: 10.3748/wjg.v32.i13.115440]
World J Gastroenterol. Apr 7, 2026; 32(13): 115440 Published online Apr 7, 2026. doi: 10.3748/wjg.v32.i13.115440
Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model
Qing-Qing Yu
Qing-Qing Yu, Clinical Research Center, Jining No. 1 People's Hospital, Jining 272000, Shandong Province, China
Author contributions: Yu QQ contributed to the discussion, design of the manuscript, the writing, and editing the manuscript, illustrations, and review of literature.
Conflict-of-interest statement: The author reports no conflicts of interest in this work.
Corresponding author: Qing-Qing Yu, Professor, Clinical Research Center, Jining No. 1 People's Hospital, No. 6 Jiankang Road, Jining 272000, Shandong Province, China. yuqingqing_lucky@163.com
Received: October 20, 2025 Revised: December 4, 2025 Accepted: January 28, 2026 Published online: April 7, 2026 Processing time: 158 Days and 18.2 Hours
Core Tip
Core Tip: Autoimmune gastritis induces gastric neuroendocrine tumors through a multistep process involving oxyntic mucosal destruction, hypergastrinemia, and enterochromaffin-like cell proliferation. Integrated clinical-endoscopic models utilizing machine learning (e.g., Boruta algorithm) outperform single-parameter approaches, with key predictors including atrophy severity, gastrin levels, and Helicobacter pylori history. These models enable personalized risk-adapted surveillance, inform vitamin B12 chemoprevention, and improve prognostic stratification by incorporating endoscopic and proliferative indices. Current limitations include single-center bias and incomplete molecular integration; future development requires multicenter validation and multimodal biomarkers.
