Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Mar 28, 2026; 32(12): 114576
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.114576
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.114576
ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death
Irfan F Corovic, Jelena M Pantic, Isidora A Stanisavljevic, Sladjana M Pavlovic, Ivan P Jovanovic, Gordana D Radosavljevic, Bojana J Simovic Markovic, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia
Irfan F Corovic, Department of Internal Medicine, General Hospital of Novi Pazar, Novi Pazar 36300, Serbia
Ivan P Jovanovic, Institute of Public Health Kragujevac, Kragujevac 34000, Serbia
Ivan P Jovanovic, Faculty of Medicine, University of East Sarajevo, Foča 73300, Bosnia and Herzegovina
Author contributions: Corovic IF and Simovic Markovic BJ were responsible for designing and coordinating the study, conducting the literature review, analyzing the data, and drafting the manuscript; Pantic JM, Stanisavljevic IA, Pavlovic SM, Jovanovic IP, and Radosavljevic GD contributed to the study design, data analysis, and manuscript preparation; Simovic Markovic BJ developed the figure; Pantic JM, Jovanovic IP, and Radosavljevic GD provided expert guidance and participated in the critical revision of the manuscript. All authors contributed to the drafting process and approved the final submitted version.
Supported by the Junior Projects of the Faculty of Medical Sciences, University of Kragujevac, Serbia, No. JP06/23; and by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia, No. 451-03-137/2025-03/200111.
Institutional animal care and use committee statement: All animal experiments were approved by the Animal Ethics Committee of the Faculty of Medical Sciences, University of Kragujevac, Serbia (approval No. 01-6172/3), and conducted in accordance with internationally accepted principles for the care and use of laboratory animals.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data relevant to this study are contained in the article.
Corresponding author: Bojana J Simovic Markovic, MD, PhD, Senior Research Associate, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovic 69, Kragujevac 34000, Serbia.
Received: September 23, 2025
Revised: November 4, 2025
Accepted: January 19, 2026
Published online: March 28, 2026
Processing time: 177 Days and 10.5 Hours
Revised: November 4, 2025
Accepted: January 19, 2026
Published online: March 28, 2026
Processing time: 177 Days and 10.5 Hours
Core Tip
Core Tip: Our study shows that suppression of tumorigenicity 2 deletion markedly reduces acute gastric mucosal injury by limiting nuclear factor kappa B and NOD-like receptor family, pyrin domain containing 3 inflammatory signaling, and subsequently immune cell infiltration, proinflammatory cytokine secretion, as well as epithelial cell death. These findings provide mechanistic insight into how interleukin-33/suppression of tumorigenicity 2 drives gastric mucosal damage and highlight this pathway as a potential therapeutic target in acute gastric injury.