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World J Gastroenterol. Mar 21, 2026; 32(11): 115809
Published online Mar 21, 2026. doi: 10.3748/wjg.v32.i11.115809
Published online Mar 21, 2026. doi: 10.3748/wjg.v32.i11.115809
Triple infection of gastric syphilis, Helicobacter pylori and human immunodeficiency virus: A case report
Jing-Li Zhang, Department of Pathology, 363 Hospital, Chengdu 610041, Sichuan Province, China
Na Wei, Tian-Ming Chen, Wen Qiu, Department of Gastroenterology, 363 Hospital, Chengdu 610041, Sichuan Province, China
Wen Qiu, Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Co-first authors: Jing-Li Zhang and Na Wei.
Co-corresponding authors: Tian-Ming Chen and Wen Qiu.
Author contributions: Zhang JL and Wei N contributed equally to this work as co-first authors and they designed the report and conducted resources; Chen TM and Qiu W wrote the manuscript and they are the co-corresponding authors of this manuscript; all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the 363 Hospital Medical Research Project Incubation Program, No. 2024FH002; and Joint Innovation Fund of Health Commission of Chengdu and Chengdu Medical College, No. WXLHCXJJ25-55.
Informed consent statement: Consent was obtained from the patient for publication of this report and any accompanying figures.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Wen Qiu, Department of Gastroenterology, 363 Hospital, No. 108 Daosangshu Street, Wuhou District, Chengdu 610041, Sichuan Province, China.
Received: October 27, 2025
Revised: December 24, 2025
Accepted: January 16, 2026
Published online: March 21, 2026
Processing time: 141 Days and 20.6 Hours
Revised: December 24, 2025
Accepted: January 16, 2026
Published online: March 21, 2026
Processing time: 141 Days and 20.6 Hours
Core Tip
Core Tip: We describe the first case of gastric syphilis, Helicobacter pylori (H. pylori) and human immunodeficiency virus triple infection. The report highlights that syphilis can produce severe “tumor-like” gastric ulceration; moreover, co-infection must be identified when H. pylori eradication fails.