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World J Gastroenterol. Mar 14, 2026; 32(10): 115957
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.115957
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.115957
Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis
Jin Song, Dan-Yan Li, Sha-Sha He, Ning Wang, Hui-Cun Zhang, Yun-Jing Bai, Bo Li, Sheng-Sheng Zhang, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
Jin Song, Sha-Sha He, Ning Wang, Hui-Cun Zhang, Yun-Jing Bai, Bo Li, Beijing Institute of Chinese Medicine, Beijing 100010, China
Xiao-Li Zhang, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
Co-corresponding authors: Bo Li and Sheng-Sheng Zhang.
Author contributions: Song J designed the study, carried out the experiments, collected data and wrote the draft; Li DY, Zhang XL, He SS and Zhang HC carried out experiments, analyzed the data and edited the paper; Wang N and Bai YJ did the project administration; Zhang SS and Li B supervised this study and co-wrote the paper; all authors proofread and approved the final manuscript.
Supported by the Special Funds of Beijing Institute of Chinese Medicine, No. YJS-2024-20.
Institutional review board statement: This study does not involve any human clinical trials or human participants; it is solely an animal study. Therefore, the corresponding clinical institutional review board approval document is not applicable.
Institutional animal care and use committee statement: This study was approved by the Beijing Institute of Traditional Chinese Medicine Institutional Animal Care and Use Committee with the ethical approval No. BJTCM-R-2025-01-05.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All the data in this paper are available from the corresponding author on reasonable request.
Corresponding author: Sheng-Sheng Zhang, MD, Doctor, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23 Meishuguanhoujie, Dongcheng District, Beijing 100010, China. zhss2000@hotmail.com
Received: November 3, 2025
Revised: December 4, 2025
Accepted: January 7, 2026
Published online: March 14, 2026
Processing time: 119 Days and 9 Hours
Revised: December 4, 2025
Accepted: January 7, 2026
Published online: March 14, 2026
Processing time: 119 Days and 9 Hours
Core Tip
Core Tip: Our study demonstrated that Chaihu-Shugan-San (CSS) restored body weight, mitigated gastric tissue histology, and alleviated intestinal metaplasia in rats with chronic atrophic gastritis, reduced levels of inflammatory cytokines, and promoted antiapoptotic pathways. CSS was shown to downregulate the nuclear factor-kappa B signaling proteins, providing insights into its mechanism of action in protection against chronic atrophic gastritis development.