Aoki Y, Kawano Y, Ga R, Endo K, Ueda J, Shimizu T, Yoshida H. Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function. World J Gastroenterol 2026; 32(10): 115167 [DOI: 10.3748/wjg.v32.i10.115167]
Corresponding Author of This Article
Youichi Kawano, MD, Associate Professor, Department of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8603, Japan. y-kawano@nms.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 14, 2026 (publication date) through Mar 2, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Aoki Y, Kawano Y, Ga R, Endo K, Ueda J, Shimizu T, Yoshida H. Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function. World J Gastroenterol 2026; 32(10): 115167 [DOI: 10.3748/wjg.v32.i10.115167]
Yuto Aoki, Ryo Ga, Department of Gastroenterological Surgery, Nippon Medical School Chiba Hokusoh Hospital, Inzai 270-1694, Chiba, Japan
Youichi Kawano, Kazuhiko Endo, Junji Ueda, Tetsuya Shimizu, Hiroshi Yoshida, Department of Gastroenterological Surgery, Nippon Medical School, Tokyo 113-8603, Japan
Author contributions: Aoki Y conceived and designed the study, obtained informed consent, collected and analyzed the data, and drafted the manuscript; Kawano Y supervised the study, provided methodological advice, and contributed to manuscript revision; Yoshida H served as the principal investigator and had overall responsibility for the study; Endo K, Ga R, Ueda J, Shimizu T assisted with data collection and chart review and provided critical comments on the manuscript.
Supported by the Designated Scholarship Donations from Otsuka Pharmaceutical Co., Ltd. to the Authors’ Institution (2018-2019).
Institutional review board statement: The study protocol was approved by the Ethics Committee of Nippon Medical School Hospital (Approval No. 30-01-1070).
Informed consent statement: Written informed consent was obtained from all participants.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: Statistical codes and de-identified datasets are available from the corresponding author upon request.
Corresponding author: Youichi Kawano, MD, Associate Professor, Department of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8603, Japan. y-kawano@nms.ac.jp
Received: October 14, 2025 Revised: December 5, 2025 Accepted: January 16, 2026 Published online: March 14, 2026 Processing time: 143 Days and 23.3 Hours
Core Tip
Core Tip: This study prospectively assessed postoperative changes in arginine vasopressin (AVP) and plasma aldosterone concentration (PAC) after liver resection and found that AVP elevation persisted longer than PAC elevation, particularly after major resections. The duration of elevated AVP closely matched the period of early postoperative fluid retention, highlighting the important role of AVP beyond the renin-angiotensin-aldosterone system. These findings suggest that targeting the V2 signaling pathway may offer strategies for optimizing fluid management and reducing complications in high-risk patients undergoing liver resection. A detailed understanding of postoperative hormonal changes is crucial for future clinical trials and therapeutic decisions.
