Kumar A, Sarangi Y, Kaw P. Gene, genetics and genetic medicines in gastroenterology: Current status and its future. World J Gastroenterol 2026; 32(1): 112496 [DOI: 10.3748/wjg.v32.i1.112496]
Corresponding Author of This Article
Ashok Kumar, FACS, Full Professor, Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. doc.ashokgupta@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 7, 2026 (publication date) through Jan 12, 2026
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Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Kumar A, Sarangi Y, Kaw P. Gene, genetics and genetic medicines in gastroenterology: Current status and its future. World J Gastroenterol 2026; 32(1): 112496 [DOI: 10.3748/wjg.v32.i1.112496]
World J Gastroenterol. Jan 7, 2026; 32(1): 112496 Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.112496
Gene, genetics and genetic medicines in gastroenterology: Current status and its future
Ashok Kumar, Yajnadatta Sarangi, Payal Kaw
Ashok Kumar, Yajnadatta Sarangi, Payal Kaw, Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Co-first authors: Ashok Kumar and Yajnadatta Sarangi.
Author contributions: Kumar A designed the concept, revised and edited the manuscript; Sarangi Y and Kaw P did the literature search and wrote the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ashok Kumar, FACS, Full Professor, Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. doc.ashokgupta@gmail.com
Received: July 28, 2025 Revised: September 9, 2025 Accepted: November 11, 2025 Published online: January 7, 2026 Processing time: 160 Days and 15.2 Hours
Core Tip
Core Tip: With advancements in genetics, there are emerging trends in better understanding of diseases and diagnosis of many undiagnosed gastrointestinal disorders. This aids in the search for newer medicines, which are pivotal to the progress of precision medicine. Genetic analysis enables accurate diagnosis, risk stratification, and individualized treatment by identifying germline mutations, somatic alterations, and epigenetic changes. It also plays a crucial role in predicting treatment response and guiding targeted therapies. Gene therapy, gene editing, and clustered regularly interspaced short palindromic repeats -associated protein systems represent promising tools for managing many complex gastrointestinal disorders and also are an aid to the conventional treatment and has a very promising future.
