Gene, genetics and genetic medicines in gastroenterology: Current status and its future

Core Tip

Core Tip: With advancements in genetics, there are emerging trends in better understanding of diseases and diagnosis of many undiagnosed gastrointestinal disorders. This aids in the search for newer medicines, which are pivotal to the progress of precision medicine. Genetic analysis enables accurate diagnosis, risk stratification, and individualized treatment by identifying germline mutations, somatic alterations, and epigenetic changes. It also plays a crucial role in predicting treatment response and guiding targeted therapies. Gene therapy, gene editing, and clustered regularly interspaced short palindromic repeats -associated protein systems represent promising tools for managing many complex gastrointestinal disorders and also are an aid to the conventional treatment and has a very promising future.