Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2025; 31(6): 102070
Published online Feb 14, 2025. doi: 10.3748/wjg.v31.i6.102070
Keratin 1 modulates intestinal barrier and immune response via kallikrein kinin system in ulcerative colitis
Xiang-Qian Dong, Ying-Hui Zhang, Juan Luo, Mao-Juan Li, Lan-Qing Ma, Ya-Ting Qi, Ying-Lei Miao
Xiang-Qian Dong, Juan Luo, Mao-Juan Li, Lan-Qing Ma, Ya-Ting Qi, Ying-Lei Miao, Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Province Clinical Research Center for Digestive Diseases, Kunming 650032, Yunnan Province, China
Ying-Hui Zhang, Department of Gastroenterology, Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China
Co-first authors: Xiang-Qian Dong and Ying-Hui Zhang.
Author contributions: Dong XQ and Miao YL contributed to the study design and manuscript revision; Zhang YH and Luo J were responsible for mice feeding and colon collection; Li MJ and Zhang YH carried out the experimental procedures; Ma LQ and Qi YT conducted the data analysis; Dong XQ and Zhang YH participated in manuscript writing and revision; Miao YL participated in manuscript editing; All authors have read and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82160113; the “Xingdian Talents” Support Project of Yunnan Province, No. RLMY20220007; the Yunnan Province Clinical Research Center for Digestive Diseases, No. 202102AA100062; and the Applied Basic Research Projects of Yunnan Province, No. 2019FE001-039.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: The animal experiments were approved by the Ethics Committee of Kunming Medical University, No. SCXK (Dian) K2020-0006, Date of approval: February 9, 2021.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Lei Miao, Doctor, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Province Clinical Research Center for Digestive Diseases, No. 295 Xichang Road, Wuhua District, Kunming 650032, Yunnan Province, China. miaoyinglei@yeah.net
Received: October 8, 2024
Revised: December 6, 2024
Accepted: December 19, 2024
Published online: February 14, 2025
Processing time: 94 Days and 0.6 Hours
Core Tip

Core Tip: Keratin 1 (KRT1) plays a protective role in ulcerative colitis by modulating the kallikrein kinin system and reducing inflammation. KRT1 enhances intestinal barrier function, inhibits inflammatory cytokines, and preserves colon integrity, positioning it as a potential therapeutic target for ulcerative colitis.