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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2025; 31(45): 112518
Published online Dec 7, 2025. doi: 10.3748/wjg.v31.i45.112518
Published online Dec 7, 2025. doi: 10.3748/wjg.v31.i45.112518
Diagnostic accuracy of stereomicroscopy assessment of invasion depth in ex vivo specimens of early gastric cancer
Jing Wang, Lin Chang, Yan Yan, Chang-Qi Cao, Shi-Jie Li, Qi Wu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing 100142, China
Dong-Feng Niu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing 100142, China
Co-first authors: Jing Wang and Lin Chang.
Author contributions: Wang J and Chang L contributed equally to this work as co-first authors; Wang J, Chang L, and Wu Q designed the research study; Wang J, Chang L, Niu DF, Yan Y, Cao CQ, and Li SJ performed the research; Wang J and Chang L analyzed the data; all authors contributed to manuscript writing and approved the final version.
Supported by Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing, No. HP2024-19-503002; and Beijing Municipal Administration of Hospitals Incubating Program, No. PX2024041.
Institutional review board statement: The study was reviewed and approved by the Peking University Cancer Hospital Institutional Review Board, No. 2015KT44.
Informed consent statement: All patients provided written informed consent before participation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Wu, MD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Endoscopy Center, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China.
Received: August 6, 2025
Revised: October 8, 2025
Accepted: November 4, 2025
Published online: December 7, 2025
Processing time: 120 Days and 18.9 Hours
Revised: October 8, 2025
Accepted: November 4, 2025
Published online: December 7, 2025
Processing time: 120 Days and 18.9 Hours
Core Tip
Core Tip: This study demonstrates that stereomicroscopy effectively assesses invasion depth in early gastric cancer, achieving 93.5% accuracy for non-ulcerated lesions, although the overall accuracy was 74.0% and only 35.8% for ulcerated lesions. Tumor size (21-30 mm) and ulceration are key misdiagnosis risk factors. These findings could guide stratified endoscopic submucosal dissection strategy.