Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice

doi:10.3748/wjg.v31.i42.112566

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Nov 14, 2025 (publication date) through Nov 16, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2025; 31(42): 112566
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.112566

Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice

Xiao-Yu Wang, Fan An, Ben-Jun Wang, Wei-Wei Han

Xiao-Yu Wang, Fan An, The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250013, Shandong Province, China

Ben-Jun Wang, Wei-Wei Han, Department of Anorectal Research, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China

Co-first authors: Xiao-Yu Wang and Fan An.

Author contributions: Wang XY and An F contribute equally to this study as co-first authors; Wang XY and An F conceived and designed the commentary; An F and Wang BJ conducted literature review and analysis; Han WW contributed to drafting and critical revision of the manuscript; all authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Wei-Wei Han, PhD, Associate Professor, Department of Anorectal Research, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369 Jingshi Road, Lixia District, Jinan 250014, Shandong Province, China. hanweiwei0557@163.com

Received: July 31, 2025
Revised: September 23, 2025
Accepted: October 20, 2025
Published online: November 14, 2025
Processing time: 105 Days and 20.5 Hours

Core Tip

Core Tip: Pravda's hydrogen peroxide (H₂O₂) hypothesis provides mechanistic insights for ulcerative colitis but faces several clinical translation challenges. These include difficulties in H₂O₂ measurement, limited safety data for reducing agents, and the risk of patients abandoning proven therapies. We recommend conducting phase 2 trials, comprehensive safety assessments, and research approaches that integrate redox mechanisms with established frameworks. Collaborative strategies that balance scientific exploration with patient safety may ensure appropriate validation before clinical adoption.