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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2025; 31(42): 110449
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.110449
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.110449
Hepatoprotective effects of silybin in liver fibrosis
Xiao-Xin Liu, Shao-Zheng Song, Department of Pharmacy, School of Health and Nursing, Wuxi Taihu University, Wuxi 214064, Jiangsu Province, China
Waseem Hassan, Department of Pharmacy, COMSATS University, Islamabad, Lahore Campus, Lahore 54000, Punjab, Pakistan
Hammad Ahmed, Department of Pharmacy, Sialkot Institute of Science and Technology, Sialkot 50170, Punjab, Pakistan
Author contributions: Liu XX collect the data and write the manuscript; Waseem H collect the data and modify the language; Hammad A draw the figure; Song SZ collect the data; all authors have read the manuscript and approved it for publication.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Zheng Song, Department of Pharmacy, School of Health and Nursing, Wuxi Taihu University, No. 68 Qianrong Road, Wuxi 214064, Jiangsu Province, China. ssz0610@163.com
Received: June 10, 2025
Revised: July 20, 2025
Accepted: October 10, 2025
Published online: November 14, 2025
Processing time: 160 Days and 1.1 Hours
Revised: July 20, 2025
Accepted: October 10, 2025
Published online: November 14, 2025
Processing time: 160 Days and 1.1 Hours
Core Tip
Core Tip: Liver fibrosis, a wound-healing response to chronic hepatic injury, is driven by redox-sensitive pathways, reactive oxygen species, and pro-fibrogenic cytokines like transforming growth factor-β. Silybum marianum (milk thistle), particularly its active compound silybin, exhibits promising antioxidant and anti-fibrotic properties. This study explores the biochemical oxidative mechanisms behind fibrogenesis and highlights silibin’s potential in reversing liver fibrosis through inhibition of oxidative stress and fibrogenic signaling pathways.